Evidence map›Paper›PMID 27920589›Full record

ArticleGenetics & epigenetics2016

DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament.

Bernard F Fuemmeler, Chien-Ti Lee, Adelheid Soubry, Edwin S Iversen, Zhiqing Huang, Amy P Murtha, Joellen M Schildkraut, Randy L Jirtle, Susan K Murphy, Cathrine Hoyo

Open access · goldAbstract read
In one paragraph

Article in Genetics & epigenetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Deficiency of the paternally-expressed imprintedFrontiers in neuroscience · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Maternally expressed gene 3 in metabolic programming.Biochimica et biophysica acta. Gene regulatory mechanisms · 2020
    Review
  13. Article
  14. Article
  15. Article
  16. Observational
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Bernard F FuemmelerDepartment of Health Behavior and Policy, Virginia Commonwealth University, Richmond, VA, USA.
Chien-Ti LeeDepartment of Family Life, Brigham Young University, Provo, UT, USA.
Adelheid SoubryDepartment of Public Health and Primary Care, Katholieke Universiteit Leuven, Leuven, Belgium.
Edwin S IversenDepartment of Statistical Science, Duke University, Durham, NC, USA.
Zhiqing HuangDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.
Amy P MurthaDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.
Joellen M SchildkrautDepartment of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Randy L JirtleDepartment of Oncology, McArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Department of Sport and Exercise Sciences, Institute of Sport and Physical Activity Research (ISPAR), University of Bedfordshire, University Square, Luton, UK.
Susan K MurphyDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.
Cathrine HoyoDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.
Duke Medical Center · USBrigham Young University · USDuke University · USUniversity of Virginia · USVirginia Commonwealth University · US

Funding

Translational Research Support CoreP30ES025128 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Sue Fenton · 2015 to 2026
$18.3M
Project 3: Epigenomic Consequences of Early Life Environmental Tobacco Smoke P01ES022831 · NIEHS · DUKE UNIVERSITY · PI MURPHY, SUSAN KAY · 2013 to 2018
$4.1M
Research Core 3: Environmental Health PolicyP30ES011961 · NIEHS · DUKE UNIVERSITY · PI DI GIULIO, RICHARD · 2004 to 2009
$4.1M
Obesity and deregulation of imprinted genes in early lifeR01DK085173 · NIDDK · DUKE UNIVERSITY · PI HOYO, CATHRINE, MURPHY, SUSAN KAY · 2010 to 2013
$2.3M
Epigenetic influence on early childhood self-regulation capacities and obesityR21AG041048 · NIA · DUKE UNIVERSITY · PI FUEMMELER, BERNARD F · 2011 to 2012
$432k
In-utero Exposure and Infant Loss of IGF2 ImprintingR21ES014947 · NIEHS · DUKE UNIVERSITY · PI HOYO, CATHRINE · 2006 to 2007
$384k
NIA NIH HHS R21 AG041048NIDDK NIH HHS R01 DK085173NIEHS NIH HHS P01 ES022831NIEHS NIH HHS P30 ES011961NIEHS NIH HHS P30 ES025128NIEHS NIH HHS R21 ES014947
6 · The paper itself

Abstract

backgroundDNA methylation of the differentially methylated regions (DMRs) of imprinted genes is relevant to neurodevelopment.

methodsDNA methylation status of the DMRs of nine imprinted genes in umbilical cord blood leukocytes was analyzed in relation to infant behaviors and temperament (n = 158).

results

conclusionWhile the small sample size limits inference, these pilot data support gene-specific associations between epigenetic differences in regulatory regions of imprinted domains at birth and later infant temperament.

Indexed as

DNA methylationepigeneticsimprinted genesinfant temperament

Identifiers

PMID27920589
PMCPMC5127604
OpenAlexW2557750946

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.