Evidence map›Paper›PMID 27920569›Full record

ReviewInternational journal of nephrology and renovascular disease2016

Does calcium channel blockade have a role in prevention of expression of sepsis in renal transplant recipients?

John A D'Elia, Ray E Gleason, Anthony P Monaco, Larry A Weinrauch

Open access · goldAbstract readReview
In one paragraph

Review in International journal of nephrology and renovascular disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

John A D'EliaKidney and Hypertension Section, Joslin Diabetes Center, Boston, MA; Departments of Surgery and Medicine, Beth Israel Deaconess Medical Center, Boston, MA; Harvard Medical School, Boston MA.
Ray E GleasonHarvard Medical School, Boston MA.
Anthony P MonacoDepartments of Surgery and Medicine, Beth Israel Deaconess Medical Center, Boston, MA; Harvard Medical School, Boston MA.
Larry A WeinrauchKidney and Hypertension Section, Joslin Diabetes Center, Boston, MA; Departments of Surgery and Medicine, Beth Israel Deaconess Medical Center, Boston, MA; Harvard Medical School, Boston MA; Department of Medicine, Mount Auburn Hospital, Cambridge, MA, USA.
Harvard University · USJoslin Diabetes Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many antihypertensive agents have been demonstrated to assist in preservation of kidney function, among them those that modulate calcium channels. Calcium channel blockers may also be of value in protecting hemodialysis patients from complications of sepsis. In diabetic recipients of kidney transplant allografts treated with cyclosporine, calcium channel blockade has been retrospectively linked to improved graft preservation and to fewer episodes of sepsis. This brief review outlines clinical and experimental publications on potential protection from sepsis by addition of calcium channel blockers to standard antibiotic therapy in individuals who may or may not have normal kidney function, or in the presence or absence of immunosuppression. Such mechanisms include blockade of antibiotic cytosolic extrusion in the cases of Pneumococci,

Indexed as

calcium channel blockaderenal transplanttransplantation sepsis

Identifiers

PMID27920569
PMCPMC5125997
OpenAlexW2549645717

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.