Evidence map›Paper›PMID 27920532›Full record

ArticleInternational journal of nanomedicine

The effect of magnetic nanoparticles on neuronal differentiation of induced pluripotent stem cell-derived neural precursors.

Klára Jiráková, Monika Šeneklová, Daniel Jirák, Karolína Turnovcová, Magda Vosmanská, Michal Babič, Daniel Horák, Pavel Veverka, Pavla Jendelová

Abstract read
In one paragraph

Article in International journal of nanomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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  6. Synergistic effect of electromagnetic fields and nanomagnetic particles on osteogenesis through calcium channels and p-ERK signaling.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Klára JirákováDepartment of Neuroscience, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic.
Monika ŠeneklováDepartment of Neuroscience, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic; Department of Neuroscience, Second Faculty of Medicine, Charles University.
Daniel JirákMR-Unit, Radiodiagnostic and Interventional Radiology Department, Institute for Clinical and Experimental Medicine; Department of Biophysics, Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University.
Karolína TurnovcováDepartment of Neuroscience, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic.
Magda VosmanskáDepartment of Analytical Chemistry, University of Chemistry and Technology.
Michal BabičDepartment of Polymer Particles, Institute of Macromolecular Chemistry.
Daniel HorákDepartment of Polymer Particles, Institute of Macromolecular Chemistry.
Pavel VeverkaDepartment of Magnetics and Superconductors, Institute of Physics, ASCR, Prague, Czech Republic.
Pavla JendelováDepartment of Neuroscience, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic; Department of Neuroscience, Second Faculty of Medicine, Charles University.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMagnetic resonance (MR) imaging is suitable for noninvasive long-term tracking. We labeled human induced pluripotent stem cell-derived neural precursors (iPSC-NPs) with two types of iron-based nanoparticles, silica-coated cobalt zinc ferrite nanoparticles (CZF) and poly-l-lysine-coated iron oxide superparamagnetic nanoparticles (PLL-coated γ-Fe MATERIALS AND

methodsWe investigated the effect of these two contrast agents on neural precursor cell proliferation and differentiation capability. We further defined the intracellular localization and labeling efficiency and analyzed labeled cells by MR.

resultsCell proliferation was not affected by PLL-coated γ-Fe

conclusionOur results show that cells labeled with PLL-coated γ-Fe

Indexed as

Cell DifferentiationCell ProliferationCells, CulturedContrast MediaFemaleFetusFibroblastsFlow CytometryHumansImmunoenzyme TechniquesInduced Pluripotent Stem CellsLungLysineMagnetic Resonance ImagingMagnetite NanoparticlesMicroscopy, Electron, TransmissionContrast MediaLysineMagnetite Nanoparticlescell differentiationferritesmagnetic resonance imagingneural precursorssuperparamagnetic iron oxide nanoparticles

Identifiers

PMID27920532
PMCPMC5125991

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.