ArticleInternational journal of nanomedicine
Macrophages participate in local and systemic inflammation induced by amorphous silica nanoparticles through intratracheal instillation.
Article in International journal of nanomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Lung inflammation induced by silica particles triggers hippocampal inflammation, synapse damage and memory impairment in mice.Journal of neuroinflammation · 2022Article
- Pulmonary Toxicity of Silica Linked to Its Micro- or Nanometric Particle Size and Crystal Structure: A Review.Nanomaterials (Basel, Switzerland) · 2022Review
- Inhaled silica nanoparticles cause chronic kidney disease in rats.American journal of physiology. Renal physiology · 2022Article
- Genotoxicity and Gene Expression in the Rat Lung Tissue following Instillation and Inhalation of Different Variants of Amorphous Silica Nanomaterials (aSiONanomaterials (Basel, Switzerland) · 2021Article
- PARP-1 overexpression does not protect HaCaT cells from DNA damage induced by SiOToxicology research · 2021Article
- Nearly free surface silanols are the critical molecular moieties that initiate the toxicity of silica particles.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction.Particle and fibre toxicology · 2020Article
- Safer-by-design flame-sprayed silicon dioxide nanoparticles: the role of silanol content on ROS generation, surface activity and cytotoxicity.Particle and fibre toxicology · 2019Article
- The chronic effect of amorphous silica nanoparticles and benzo[Toxicology research · 2019Article
- Co-Exposure to SiOInternational journal of environmental research and public health · 2019Article
- Qingre Baidu mixture-induced effect of AI-2 onExperimental and therapeutic medicine · 2019Article
- Spherical silica nanoparticles promote malignant transformation of BEAS-2B cells by stromal cell-derived factor-1α (SDF-1α).The Journal of international medical research · 2019Article
- Blockage of TGF-BioMed research international · 2019Article
- Repeated intravenous administration of silica nanoparticles induces pulmonary inflammation and collagen accumulation via JAK2/STAT3 and TGF-β/Smad3 pathways in vivo.International journal of nanomedicine · 2019Article
- Effects of Ultrasonic Dispersion Energy on the Preparation of Amorphous SiO₂ Nanomaterials for In Vitro Toxicity Testing.Nanomaterials (Basel, Switzerland) · 2018Article
- Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life.International journal of nanomedicine · 2018Article
- Toxicology of silica nanoparticles: an update.Archives of toxicology · 2017Review
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Silica nanoparticles (SiNPs) are amongst the most commonly used materials in the field of nanomedicine and, therefore, their influence on organisms has drawn increasing attention in recent years. Most reports have focused on the single tissue reactions induced by SiNPs. Herein, the reaction of primary organs to SiNPs following intratracheal instillation in mice was analyzed by histopathology and ultrastructure observation. Following elucidation of the role of macrophages in local and systemic inflammation, the underlying mechanisms were explored using a macrophage cell line in vitro. The results suggest that macrophages swallow the SiNPs and secrete inflammatory factors by activating the NLRP3 inflammasome, thus participating in local and systemic inflammation.
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