Evidence map›Paper›PMID 27920513›Full record

Trial reportInternational journal of chronic obstructive pulmonary disease2016

Bronchodilator efficacy of 18 μg once-daily tiotropium inhalation via Discair

Pinar Yildiz, Mesut Bayraktaroglu, Didem Gorgun, Funda Secik

Registry-linked trialOpen access · goldAbstract readClinical Trial, Phase IVComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of chronic obstructive pulmonary disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02541006 (A Randomized, Parallel-group, Phase IV Study to Compare the Bronchodilator Efficacy of Tiotropium), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02541006 phase4completednot on this map

A Randomized, Parallel-group, Phase IV Study to Compare the Bronchodilator Efficacy of Tiotropium (18 µg Once Daily [od]) Delivered Via a DISCAIR With Tiotropium (18 µg od) Delivered Via a HandiHaler®, in Patients With Moderate-to-severe COPD

TypeinterventionalSponsorNeutec Ar-Ge San ve Tic A.ŞRan2014 to 2015Enrolled58ConditionsCOPDArmsTiotropium 18 mcg
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Pinar YildizClinics of Chest Diseases, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey.
Mesut BayraktarogluClinics of Chest Diseases, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey.
Didem GorgunClinics of Chest Diseases, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey.
Funda SecikClinics of Chest Diseases, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey.
Yedikule Teaching Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the bronchodilator efficacy of 18 μg once-daily tiotropium inhalation administered via Discair PATIENTS AND

methodsFifty-eight patients with moderate-to-severe COPD were enrolled in this randomized, active-controlled, parallel-group, open-label, Phase IV non-inferiority trial. Patients were randomly assigned to a test group (n=29, inhalation with Discair) or a reference group (n=29, inhalation with HandiHaler). The primary efficacy parameter was the average maximum change in forced expiratory volume in 1 second (FEV

resultsThe test inhaler was non-inferior to the reference inhaler in terms of maximum change in FEV

conclusionOur findings show that the Discair was non-inferior to the HandiHaler. More specifically, these devices had similar clinical efficacy in terms of time-dependent response over 24 h for patients with moderate-to-severe COPD.

Indexed as

Dry Powder InhalersAdministration, InhalationAgedBronchodilator AgentsCholinergic AntagonistsEquipment DesignFemaleForced Expiratory VolumeHumansLungMaleMiddle AgedPulmonary Disease, Chronic ObstructiveSeverity of Illness IndexTime FactorsTiotropium BromideBronchodilator AgentsCholinergic AntagonistsTiotropium Bromidebronchodilator efficacyDiscair®HandiHaler®non-inferiorityspirometrytiotropium

Identifiers

PMID27920513
PMCPMC5125983
OpenAlexW2552590357

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.