ArticlePatient preference and adherence2016
Gender- and age-related treatment compliance in patients with osteoporosis in Germany.
Article in Patient preference and adherence, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of thiazides on serum and urinary calcium levels and bone mineral density in patients with osteoporosis: a systematic review and meta-analysis.Drug design, development and therapy · 2018Pooled it
- Effect of A Patient Reminder Program on Adherence in Postmenopausal Women with Osteoporosis Receiving Oral Bisphosphonate Treatment: A Randomized Clinical Control Trial.Calcified tissue international · 2025Trial
- Use of antiosteoporotic medication in the Danish ROSE population-based screening study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Trial
- Medical treatment of osteoporosis in osteoporotic vertebral fractures - Results from the prospective EOFTT multicenter study.Brain & spine · 2026Article
- Bisphosphonate compliance in Japan from the perspective of product, formulation, and patient characteristics: analysis of medical insurance claim data.Journal of pharmaceutical health care and sciences · 2025Article
- Effect of gender on the evolution of pain and quality of life after treatment of symptomatic vertebral fragility fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- [Osteoporosis-risk evaluation and case finding].Orthopadie (Heidelberg, Germany) · 2023Review
- BeCause of the Effect the role of health messages ordering on behavioral change intention.Journal of psycholinguistic research · 2022Article
- Observational
- Osteoporotic fractures and subsequent fractures: imminent fracture risk from an analysis of German real-world claims data.Archives of gynecology and obstetrics · 2021Observational
- Keep Calm and Stay Safe: The Relationship between Anxiety and Other Psychological Factors, Media Exposure and Compliance with COVID-19 Regulations.International journal of environmental research and public health · 2021Article
- Development and validation of a questionnaire to determine medical orders non-adherence: a sequential exploratory mixed-method study.BMC health services research · 2021Article
- Impact of COVID-19 on Dental Emergency Services in Cluj-Napoca Metropolitan Area: A Cross-Sectional Study.International journal of environmental research and public health · 2020Article
- Adherence to fracture liaison service programs in patients over 70: the hidden part of the iceberg.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Differences in drug use between men and women: an Italian cross sectional study.BMC women's health · 2017Article
- Frequency and predictors of compliance among patients taking antihypertensive medicines.Indian heart journalObservational
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe purpose of this study was to analyze treatment compliance in osteoporotic patients treated with osteoporosis medications in Germany.
methodsPatients included in the analysis had been diagnosed with osteoporosis with or without fractures and started anti-osteoporotic therapy (bisphosphonates, denosumab, or strontium ranelate) between 2011 and 2014 in a general (GP) or orthopedic practice (OP) setting in Germany. Data pertaining to 6,221 individuals followed in GP and 4,044 individuals followed in OP were analyzed retrospectively. The last follow-up was in December 2015. The main outcome measure was the compliance within the one-year period after the index prescription date. Compliance was measured indirectly and was based on the mean possession ratio (MPR). A multivariate logistic regression model was used to determine the association between MPR (dependent variable) and age, gender, type of practice, type of osteoporosis treatment, therapy frequency, and history of fracture (covariates).
resultsThe mean age of the study group was 73.3 years, and 13.2% of subjects were men. Regarding type of practice, 60.6% of individuals were followed in GP and 39.4% in OP. Noncompliance was observed in 55.2% of the patients. Patients in the age group ≤60 years were at a higher risk of being noncompliant when compared to those in the age group of 61-70 years. Men and patients who received oral drugs were also more likely to be noncompliant than women and patients who received injectable or intravenous drugs. Finally, therapies that were given every three or six months were associated with a decrease in the risk of noncompliance when compared to weekly therapy, whereas daily and monthly treatments were associated with an increased risk.
conclusionCompliance is insufficient in osteoporotic patients treated with osteoporosis medications.
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