ArticleStatistical methods in medical research2018
An optimal Wilcoxon-Mann-Whitney test of mortality and a continuous outcome.
Article in Statistical methods in medical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
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- Multi-Metaomics Unveils the Development Process of Microbial Communities During the Fermentation of Baobaoqu.Foods (Basel, Switzerland) · 2025Article
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- Gut microbiota dysbiosis and metabolic shifts in pediatric norovirus infection: a metagenomic study in Northeast China.Frontiers in cellular and infection microbiology · 2025Article
- The environmental microbial retrieving assessment of cell-processing facilities for cell therapy in a hospital laboratory.Microbiology spectrum · 2024Article
- Transcriptomic and Metatranscriptomic Analyses Provide New Insights into the Response of the Pea AphidInsects · 2024Article
- Long-Term Neuropsychiatric Developmental Defects after Neonatal Organophosphate Exposure: Mitigation by Synthetic Neurosteroids.The Journal of pharmacology and experimental therapeutics · 2024Article
- Alterations in Gut Microbiota Correlate With Hematological Injuries Induced by Radiation in Beagles.International journal of microbiology · 2024Article
- Differences in Physiological Performance and Gut Microbiota between Deep-Sea and Coastal Aquaculture of Thachinotus Ovatus: A Metagenomic Approach.Animals : an open access journal from MDPI · 2023Article
- Dysbiosis of Oral Microbiota and Metabolite Profiles Associated with Type 2 Diabetes Mellitus.Microbiology spectrum · 2023Article
- Metagenomic Analysis of Gut Microbiome in Gout Patients with Different Chinese Traditional Medicine Treatments.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Article
- Phenobarbital as alternate anticonvulsant for organophosphate-induced benzodiazepine-refractory status epilepticus and neuronal injury.Epilepsia open · 2020Article
- Optimal sample size planning for the Wilcoxon-Mann-Whitney test.Statistics in medicine · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We consider a two-group randomized clinical trial, where mortality affects the assessment of a follow-up continuous outcome. Using the worst-rank composite endpoint, we develop a weighted Wilcoxon-Mann-Whitney test statistic to analyze the data. We determine the optimal weights for the Wilcoxon-Mann-Whitney test statistic that maximize its power. We derive a formula for its power and demonstrate its accuracy in simulations. Finally, we apply the method to data from an acute ischemic stroke clinical trial of normobaric oxygen therapy.
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