Evidence map›Paper›PMID 27920206›Full record

ArticleThe Journal of biological chemistry2017

Activation of D2 Dopamine Receptors in CD133+ve Cancer Stem Cells in Non-small Cell Lung Carcinoma Inhibits Proliferation, Clonogenic Ability, and Invasiveness of These Cells.

Soumyabrata Roy, Kai Lu, Mukti Kant Nayak, Avishek Bhuniya, Tithi Ghosh, Suman Kundu, Sarbari Ghosh, Rathindranath Baral, Partha Sarathi Dasgupta, Sujit Basu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 53 citations in OpenAlex.

  1. Trial
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  8. Cancer and neurotransmitter receptors.Chinese medical journal · 2025
    Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. The tumor-nerve circuit in breast cancer.Cancer metastasis reviews · 2023
    Review
  16. Review
  17. Review
  18. Lung Cancer Stem Cells and Their Clinical Implications.Cold Spring Harbor perspectives in medicine · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Soumyabrata RoyFrom the Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata 700026, India.
Kai Luthe Department of Pathology, Ohio State University, Columbus, Ohio 43210.
Mukti Kant Nayakthe Division of Virology, National Institute of Cholera and Enteric Diseases, Kolkata 700010, India.
Avishek BhuniyaFrom the Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata 700026, India.
Tithi GhoshFrom the Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata 700026, India.
Suman Kunduthe Cancer Biology and Inflammatory Disorder Division, Indian Institute of Chemical Biology, Kolkata 700032, India, and.
Sarbari GhoshFrom the Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata 700026, India.
Rathindranath BaralFrom the Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata 700026, India.
Partha Sarathi DasguptaFrom the Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata 700026, India, partha42002@yahoo.com.
Sujit Basuthe Department of Pathology, Ohio State University, Columbus, Ohio 43210, sujit.basu@osumc.edu.
Chittaranjan National Cancer Institute · INThe Ohio State University · USIndian Institute of Chemical Biology · INNational Institute of Cholera and Enteric Diseases · IN

Funding

Role of dopamine in the regulation of endothelial cell functions in diabetesR01DK098045 · NIDDK · OHIO STATE UNIVERSITY · PI BASU, SUJIT · 2012 to 2016
$1.6M
Dopamine as a therapeutic agent in stomach cancerR01CA169158 · NCI · OHIO STATE UNIVERSITY · PI BASU, SUJIT · 2013 to 2017
$1.6M
Role of chebulinic acid in angiogenesisR01HL131405 · NHLBI · OHIO STATE UNIVERSITY · PI BASU, SUJIT · 2016 to 2019
$1.5M
NCI NIH HHS R01 CA169158NHLBI NIH HHS R01 HL131405NIDDK NIH HHS R01 DK098045
6 · The paper itself

Abstract

Lung carcinoma is the leading cause of cancer-related death worldwide, and among this cancer, non-small cell lung carcinoma (NSCLC) comprises the majority of cases. Furthermore, recurrence and metastasis of NSCLC correlate well with CD133+ve tumor cells, a small population of tumor cells that have been designated as cancer stem cells (CSC). We have demonstrated for the first time high expression of D

Indexed as

AC133 AntigenCell ProliferationGene Expression Regulation, NeoplasticA549 CellsAnimalsCarcinoma, Non-Small-Cell LungHeterograftsHumansLung NeoplasmsMAP Kinase Signaling SystemMatrix Metalloproteinase 9MiceMice, NudeMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Neoplasm InvasivenessAC133 AntigenMAPK1 protein, humanMatrix Metalloproteinase 9Mitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3MMP9 protein, humanNeoplasm ProteinsOctamer Transcription Factor-3POU5F1 protein, humanPROM1 protein, humanReceptors, Dopamine D2cancercancer biologycancer stem cellscancer therapyD2 receptorsdopaminelung cancersignal transduction

Identifiers

PMID27920206
PMCPMC5241722
OpenAlexW2560230696

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.