ReviewCold Spring Harbor perspectives in biology2017
Systems Chronobiology: Global Analysis of Gene Regulation in a 24-Hour Periodic World.
Review in Cold Spring Harbor perspectives in biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- The phenology of the European flat oyster (Ostrea edulis) and its environmental drivers.Scientific reports · 2026Article
- Time-restricted feeding modulates neuron-glial interactions and circadian rhythm in the spinal cord of male Wistar rats fed a high-fat diet.Spinal cord · 2025Article
- Characterization of the daily and circadian valve behavior of the European flat oyster Ostrea edulis.Scientific reports · 2025Article
- The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research.Nature metabolism · 2025Review
- Role of Circadian Clock on the Pathogenesis and Lifestyle Management in Non-Alcoholic Fatty Liver Disease.Nutrients · 2022Review
- Comprehensive analysis of the circadian nuclear and cytoplasmic transcriptome in mouse liver.PLoS genetics · 2022Article
- Characterizing the modern light environment and its influence on circadian rhythms.Proceedings. Biological sciences · 2021Article
- Oscillating and stable genome topologies underlie hepatic physiological rhythms during the circadian cycle.PLoS genetics · 2021Article
- Experimental dopaminergic neuron lesion at the area of the biological clock pacemaker, suprachiasmatic nuclei (SCN) induces metabolic syndrome in rats.Diabetology & metabolic syndrome · 2021Article
- Widely rhythmic transcriptome iniScience · 2021Article
- Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Space-time logic of liver gene expression at sub-lobular scale.Nature metabolism · 2021Article
- Daily transcriptomes of the copepod Calanus finmarchicus during the summer solstice at high Arctic latitudes.Scientific data · 2020Article
- Overcoming Compensatory Mechanisms toward Chronic Drug Administration to Ensure Long-Term, Sustainable Beneficial Effects.Molecular therapy. Methods & clinical development · 2020Review
- Article
- Critical role of deadenylation in regulating poly(A) rhythms and circadian gene expression.PLoS computational biology · 2020Article
- Low-dimensional Dynamics of Two Coupled Biological Oscillators.Nature physics · 2019Article
- A Multi-Layered Study on Harmonic Oscillations in Mammalian Genomics and Proteomics.International journal of molecular sciences · 2019Article
- Moonlight cycles synchronize oyster behaviour.Biology letters · 2019Article
- A Systems-Level Analysis Reveals Circadian Regulation of Splicing in Colorectal Cancer.EBioMedicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammals have evolved an internal timing system, the circadian clock, which synchronizes physiology and behavior to the daily light and dark cycles of the Earth. The master clock, located in the suprachiasmatic nucleus (SCN) of the brain, takes fluctuating light input from the retina and synchronizes other tissues to the same internal rhythm. The molecular clocks that drive these circadian rhythms are ticking in nearly all cells in the body. Efforts in systems chronobiology are now being directed at understanding, on a comprehensive scale, how the circadian clock controls different layers of gene regulation to provide robust timing cues at the cellular and tissue level. In this review, we introduce some basic concepts underlying periodicity of gene regulation, and then highlight recent genome-wide investigations on the propagation of rhythms across multiple regulatory layers in mammals, all the way from chromatin conformation to protein accumulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.