ArticleBMJ (Clinical research ed.)2016
Development and validation of risk prediction model for venous thromboembolism in postpartum women: multinational cohort study.
Article in BMJ (Clinical research ed.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 57 papers, 7 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Predicting Patient-level New Onset Atrial Fibrillation From Population-based Nationwide Electronic Health Records: A Precision Medicine Investigation Using Artificial Intelligence
Assessing Women's Preferences for Postpartum Thromboprophylaxis: the PREFER-PostPartum
Who cites it
57 citing papers in PubMed, 7 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Pre-Existing and Gestational Diabetes and Risk of Maternal Venous Thromboembolism: A Systematic Review and Meta-Analysis of Observational Studies.BJOG : an international journal of obstetrics and gynaecology · 2025Pooled it
- Thromboprophylaxis during pregnancy and the puerperium: a systematic review and economic evaluation to estimate the value of future research.Health technology assessment (Winchester, England) · 2024Pooled it
- Risk assessment models for venous thromboembolism in pregnancy and in the puerperium: a systematic review.BMJ open · 2022Pooled it
- Development and validation of a prediction model for fat mass in children and adolescents: meta-analysis using individual participant data.BMJ (Clinical research ed.) · 2019Pooled it
- Prognostic Models for Predicting Overall Survival in Patients with Primary Gastric Cancer: A Systematic Review.BioMed research international · 2019Pooled it
- American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy.Blood advances · 2018Guideline
- Postpartum venous thromboembolism prophylaxis may cause more harm than benefit: a critical analysis of international guidelines through an evidence-based lens.BJOG : an international journal of obstetrics and gynaecology · 2018Pooled it
- Validation of a prediction model for postpartum hospital use in geographic contexts with greater rural representation.American journal of obstetrics & gynecology MFM · 2026Article
- Development and internal validation of a clinical prediction model for venous thromboembolism in patients with renal insufficiency.Scientific reports · 2026Article
- Diagnostic accuracy of D-dimer for predicting postpartum venous thromboembolism: a systematic review and meta-analysis.Thrombosis journal · 2026Review
- Postoperative venous thromboembolism following cesarean delivery: prevalence, pathophysiology, diagnosis, treatment, and prevention.American journal of obstetrics and gynecology · 2026Review
- Single Center Implementation of a Postpartum Pharmacologic Thromboprophylaxis Protocol.American journal of perinatology · 2026Article
- Pregnancy-Related Venous Thromboembolism Risk Perception and Prevention in Risk-Averse Times-Significant Change Required: a Commentary.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Improving Clinical Prediction of Pulmonary Embolism in Pregnancy and Postpartum by Modifying Wells Score with a Population Specific Risk Factor:Sultan Qaboos University medical journal · 2025Article
- Multicenter external validation of prediction models for clinical outcomes after spinal fusion for lumbar degenerative disease.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- Tutorial: dos and don'ts in clinical prediction research for venous thromboembolism.Research and practice in thrombosis and haemostasis · 2024Article
- Development and external validation of a prediction model for venous thromboembolism in systemic lupus erythematosus.RMD open · 2023Article
- Postpartum readmission for hypertension and pre-eclampsia: development and validation of a predictive model.BJOG : an international journal of obstetrics and gynaecology · 2023Article
- Development and validation of the lung donor (LUNDON) acceptability score for pulmonary transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023Article
- Transparent reporting of multivariable prediction models developed or validated using clustered data (TRIPOD-Cluster): explanation and elaboration.BMJ (Clinical research ed.) · 2023Article
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo develop and validate a risk prediction model for venous thromboembolism in the first six weeks after delivery (early postpartum).
designCohort study.
settingRecords from England based Clinical Practice Research Datalink (CPRD) linked to Hospital Episode Statistics (HES) and data from Sweden based registry.
participantsAll pregnant women registered with CPRD-HES linked data between 1997 and 2014 and Swedish medical birth registry between 2005 and 2011 with postpartum follow-up.
main outcome measureMultivariable logistic regression analysis was used to develop a risk prediction model for postpartum venous thromboembolism based on the English data, which was externally validated in the Swedish data.
results433 353 deliveries were identified in the English cohort and 662 387 in the Swedish cohort. The absolute rate of venous thromboembolism was 7.2 per 10 000 deliveries in the English cohort and 7.9 per 10 000 in the Swedish cohort. Emergency caesarean delivery, stillbirth, varicose veins, pre-eclampsia/eclampsia, postpartum infection, and comorbidities were the strongest predictors of venous thromboembolism in the final multivariable model. Discrimination of the model was similar in both cohorts, with a C statistic above 0.70, with excellent calibration of observed and predicted risks. The model identified more venous thromboembolism events than the existing national English (sensitivity 68% v 63%) and Swedish guidelines (30% v 21%) at similar thresholds.
conclusionA new prediction model that quantifies absolute risk of postpartum venous thromboembolism has been developed and externally validated. It is based on clinical variables that are available in many developed countries at the point of delivery and could serve as the basis for real time decisions on obstetric thromboprophylaxis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.