Evidence map›Paper›PMID 27919666›Full record

ArticleDevelopmental biology2017

Calreticulin is a secreted BMP antagonist, expressed in Hensen's node during neural induction.

Irene De Almeida, Nidia M M Oliveira, Rebecca A Randall, Caroline S Hill, John M McCoy, Claudio D Stern

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Ventral body wall closure: Mechanistic insights from mouse models and translation to human pathology.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Review
  2. Article
  3. Sostdc1 is expressed in all major compartments of developing and adult mammalian eyes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Irene De AlmeidaDepartment of Cell & Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
Nidia M M OliveiraDepartment of Cell & Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
Rebecca A RandallFrancis Crick Institute, Midland Road, London NW1 1AT, UK.
Caroline S HillFrancis Crick Institute, Midland Road, London NW1 1AT, UK.
John M McCoyGenetics Institute, Boston, MA, USA.
Claudio D SternDepartment of Cell & Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
University College London · GBThe Francis Crick Institute · GB

Funding

EARLY EVENTS IN NEURAL AND HOMEOGENETIC INDUCTIONR01MH060156 · NIMH · UNIVERSITY COLLEGE LONDON · PI STERN, CLAUDIO D · 1999 to 2005
$867k
Cancer Research UK 15681Medical Research Council G0400559NIMH NIH HHS R01 MH060156
6 · The paper itself

Abstract

Hensen's node is the "organizer" of the avian and mammalian early embryo. It has many functions, including neural induction and patterning of the ectoderm and mesoderm. Some of the signals responsible for these activities are known but these do not explain the full complexity of organizer activity. Here we undertake a functional screen to discover new secreted factors expressed by the node at this time of development. Using a Signal Sequence Trap in yeast, we identify several candidates. Here we focus on Calreticulin. We show that in addition to its known functions in intracellular Calcium regulation and protein folding, Calreticulin is secreted, it can bind to BMP4 and act as a BMP antagonist in vivo and in vitro. Calreticulin is not sufficient to account for all organizer functions but may contribute to the complexity of its activity.

Indexed as

Embryonic InductionAnimalsBone Morphogenetic ProteinsCalnexinCalreticulinChickensFibroblast Growth FactorsHEK293 CellsHumansNerve TissueNeural PlateOrganizers, EmbryonicSignal TransductionSolubilityBone Morphogenetic ProteinsCalnexinCalreticulinFibroblast Growth FactorsCalcium-binding proteinsCalnexinChick embryoGastrulationNeural plateNeurulationPhospho-Smad

Identifiers

PMID27919666
PMCPMC5231319
OpenAlexW2557505320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.