Evidence map›Paper›PMID 27919582›Full record

ArticleThe Journal of arthroplasty2017

External Validation of a Prognostic Model for Predicting Nonresponse Following Knee Arthroplasty.

Daniel L Riddle, Gregory J Golladay, William A Jiranek, Robert A Perera

Open access · greenAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of arthroplasty, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Daniel L RiddleDepartment of Physical Therapy, West Hospital, Virginia Commonwealth University, Richmond, Virginia; Department of Orthopaedic Surgery, West Hospital, Virginia Commonwealth University, Richmond, Virginia; Department of Rheumatology, McGuire Hall, Virginia Commonwealth University, Richmond, Virginia.
Gregory J GolladayDepartment of Orthopaedic Surgery, Virginia Commonwealth University, Richmond, Virginia.
William A JiranekDepartment of Orthopaedic Surgery, Virginia Commonwealth University, Richmond, Virginia.
Robert A PereraDepartment of Biostatistics, Virginia Commonwealth University, Richmond, Virginia.
Virginia Commonwealth University · US

Funding

DATA COORDINATING CENTER FOR THE OSTEOARTHRITIS INITIATIVE-264022258N01AR022258 · NIAMS · UNIVERSITY OF CALIFORNIA SYS OFFICE/PRES · 2003 to 2003
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CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-264022259-264022259N01AR022259 · NIAMS · UNIVERSITY OF MARYLAND AT BALT · PI HOCHBERG, MARC C. · 2002 to 2006
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CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22260N01AR022260 · NIAMS · UNIVERSITY OF PITTSBURGH · PI KWOH, KENT · 2002 to 2006
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CLINICAL CENTER FOR THE OSTEOARTHRITIS-264022262-264022262N01AR022262 · NIAMS · THE MEMORIAL HOSPITAL · PI ASSAF, ANNLOUISE R. · 2002 to 2006
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NIAMS NIH HHS N01 AR022258NIAMS NIH HHS N01 AR022259NIAMS NIH HHS N01 AR022260NIAMS NIH HHS N01 AR022262
6 · The paper itself

Abstract

backgroundInstruments designed to predict the extent of pain and function following knee arthroplasty (KA) recovery has strong potential to guide patients and clinicians in shared decision making. Our purpose was to test the external validity of a recently developed prognostic instrument designed to estimate the probability of nonresponse following KA.

methodsWe used data from the Osteoarthritis Initiative (OAI), a 9-year multisite National Institutes of Health study designed to examine the natural history of knee osteoarthritis in 4796 subjects. A total of 427 subjects underwent KA over the study period. Dowsey et al examined the prognostic role of obesity, general mental health, pain and function, and Kellgren and Lawrence knee osteoarthritis grades. Calibration of the prognostic model was determined using a calibration curve. The c-statistic was used to indicate discrimination of the model.

resultsIn the primary analysis, 63 (19.3%) of 326 subjects in OAI were classified as nonresponders. The calibration curve generated from OAI data indicated poor calibration relative to the recently developed instrument. Discrimination as measured by the c-statistic was 0.76.

conclusionThe external validity of the prognostic instrument was partially supported. While discrimination of the model was very similar to the recently developed instrument, calibration was poor indicating poor agreement between actual vs predicted probabilities of nonresponse. Western Ontario and McMaster Universities Arthritis Index and Kellgren and Lawrence grades show strong potential for use in future prognostic model development. Measurements of general mental health and obesity were not prognostic for nonresponse.

Indexed as

Arthroplasty, Replacement, KneeDecision Support TechniquesAgedFemaleHumansMaleMiddle AgedNomogramsObesityOsteoarthritis, KneePainPain MeasurementPrognosisRecovery of FunctionTreatment Failurearthroplastyfunctionkneenomogrampainprognosis

Identifiers

PMID27919582
PMCPMC5362316
OpenAlexW2549631060

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.