ArticleBMC neuroscience2016
Molar loss and powder diet leads to memory deficit and modifies the mRNA expression of brain-derived neurotrophic factor in the hippocampus of adult mice.
Article in BMC neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Food Hardness Modulates Behavior, Cognition, and Brain Activation: A Systematic Review of Animal and Human Studies.Nutrients · 2023Pooled it
- Tooth Loss-Associated Mechanisms That Negatively Affect Cognitive Function: A Systematic Review of Animal Experiments Based on Occlusal Support Loss and Cognitive Impairment.Frontiers in neuroscience · 2022Pooled it
- Pooled it
- Number of natural teeth and incident cognitive impairment in older Chinese adults: A longitudinal CLHLS cohort study.Medicine · 2026Article
- Oral-Systemic Links: A Narrative Review of the Role of Periodontitis in Alzheimer's Disease Development.Cureus · 2026Review
- Advances in research on dental occlusion and brain function: neuroimaging correlates and molecular mechanisms.Frontiers in neurology · 2026Review
- Tooth loss in young mice is associated with cognitive decline and femur-bone mineral density.Odontology · 2025Article
- Malocclusion Worsens Survival Following Sepsis Due to the Disruption of Innate and Acquired Immunity.International journal of molecular sciences · 2025Article
- Masticatory Function, Sex, and Risk of Dementia Among Older Adults: A Population-Based Cohort Study.Journal of Korean medical science · 2024Article
- Occlusion dysfunction and Alzheimer's disease: Mendelian randomization study.Frontiers in aging neuroscience · 2024Article
- Long-Term Capsaicin Administration Ameliorates the Dysfunction and Astrogliosis of the Brain in Aged Mice with Missing Maxillary Molars.Nutrients · 2023Article
- Mouse maternal odontogenic infection withFrontiers in pediatrics · 2023Article
- Association between adverse oral conditions and cognitive impairment: A literature review.Frontiers in public health · 2023Review
- The Sedentary Lifestyle and Masticatory Dysfunction: Time to Review the Contribution to Age-Associated Cognitive Decline and Astrocyte Morphotypes in the Dentate Gyrus.International journal of molecular sciences · 2022Review
- Molar loss induces hypothalamic and hippocampal astrogliosis in aged mice.Scientific reports · 2022Article
- The path from trigeminal asymmetry to cognitive impairment: a behavioral and molecular study.Scientific reports · 2021Article
- Tooth loss early in life induces hippocampal morphology remodeling in senescence-accelerated mouse prone 8 (SAMP8) mice.International journal of medical sciences · 2020Article
- Environmental Impoverishment, Aging, and Reduction in Mastication Affect Mouse Innate Repertoire to Explore Novel Environments and to Assess Risk.Frontiers in neuroscience · 2019Article
- Revisiting the link between cognitive decline and masticatory dysfunction.BMC geriatrics · 2018Review
- Environmental Enrichment and Successful Aging.Frontiers in behavioral neuroscience · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is known that tooth loss is known to be a risk factor for Alzheimer's disease and soft diet feeding induces memory impairment. Recent studies have shown that brain-derived neurotrophic factor (BDNF) is associated with tooth loss or soft diet in young animal model, and that BDNF expression is decreased in patients with Alzheimer's disease. However, single or combined effect of tooth loss and/or soft diet on brain function has not fully understood. Here we examined the effect of molar loss and powder diet on memory ability and the expression of BDNF mRNA in the hippocampus of adult C57BL/6J mice. Twenty eight-weeks-old C57BL/6J mice were divided into intact molar group and extracted molar group. They were randomly divided into the I/S group (Intact upper molar teeth/Solid diet feeding), the E/S group (Extracted upper molar teeth/Solid diet feeding), the I/P group (Intact upper molar teeth/Powder diet feeding), and the E/P group (Extracted upper molar teeth/Powder diet feeding). The observation periods were 4 and 16-week. To analyze the memory ability, the step-through passive avoidance test was conducted. BDNF-related mRNA in the hippocampus was analyzed by real-time polymerase chain reaction (RT-PCR).
resultsAt 4 weeks later, we performed memory test and isolated brains to analyze. There were no differences in memory function and BDNF mRNA level between these four groups. However, at 16 weeks later, E/S and E/P group showed memory impairment, and decreased level of BDNF mRNA. Whereas, the powder diet had no effect on memory function and BDNF mRNA level even at 16 weeks later.
conclusionsThese results suggest that the effect of molar loss and powder diet on memory function and BDNF mRNA levels were different, molar loss may have a greater long-term effect on memory ability than powder diet does.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.