Evidence map›Paper›PMID 27919104›Full record

Observational studyAnnals of internal medicine2017

Dual Health Care System Use and High-Risk Prescribing in Patients With Dementia: A National Cohort Study.

Joshua M Thorpe, Carolyn T Thorpe, Walid F Gellad, Chester B Good, Joseph T Hanlon, Maria K Mor, John R Pleis, Loren J Schleiden, Courtney Harold Van Houtven

Abstract readObservational Study
In one paragraph

Observational study in Annals of internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Initiation and Persistence of Antipsychotic Medications at Hospital Discharge Among Community-Dwelling Veterans With Dementia.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025
    Article
  2. Pharmacist-Driven Deprescribing to Reduce Anticholinergic Burden in Veterans With Dementia.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2024
    Article
  3. Impact of VA Hematology/Oncology Clinical Pharmacy Practitioners in the Review of Community Prescriptions for Specialty Medications.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2024
    Article
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  9. Polypharmacy in Older Adults with Alzheimer's Disease.Medicina (Kaunas, Lithuania) · 2022
    Review
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  20. Pharmacy Integration.American health & drug benefits · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Joshua M ThorpeFrom the Center for Health Equity Research and Promotion, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, and Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, North Carolina.
Carolyn T ThorpeFrom the Center for Health Equity Research and Promotion, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, and Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, North Carolina.
Walid F GelladFrom the Center for Health Equity Research and Promotion, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, and Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, North Carolina.
Chester B GoodFrom the Center for Health Equity Research and Promotion, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, and Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, North Carolina.
Joseph T HanlonFrom the Center for Health Equity Research and Promotion, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, and Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, North Carolina.
Maria K MorFrom the Center for Health Equity Research and Promotion, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, and Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, North Carolina.
John R PleisFrom the Center for Health Equity Research and Promotion, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, and Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, North Carolina.
Loren J SchleidenFrom the Center for Health Equity Research and Promotion, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, and Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, North Carolina.
Courtney Harold Van HoutvenFrom the Center for Health Equity Research and Promotion, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, and Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, North Carolina.

Funding

VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6M
NIA NIH HHS P30 AG024827
6 · The paper itself

Abstract

backgroundRecent federal policy changes attempt to expand veterans' access to providers outside the Department of Veterans Affairs (VA). Receipt of prescription medications across unconnected systems of care may increase the risk for unsafe prescribing, particularly in persons with dementia.

objectiveTo investigate the association between dual health care system use and potentially unsafe medication (PUM) prescribing.

designRetrospective cohort study.

settingNational VA outpatient care facilities in 2010.

participants75 829 veterans with dementia who were continuously enrolled in Medicare from 2007 to 2010; 80% were VA-only users, and 20% were VA-Medicare Part D (dual) users. MEASUREMENTS: Augmented inverse propensity weighting was used to estimate the effect of dual-system versus VA-only prescribing on 4 indicators of PUM prescribing in 2010: any exposure to Healthcare Effectiveness Data and Information Set (HEDIS) high-risk medication in older adults (PUM-HEDIS), any daily exposure to prescriptions with a cumulative Anticholinergic Cognitive Burden (ACB) score of 3 or higher (PUM-ACB), any antipsychotic prescription (PUM-antipsychotic), and any PUM exposure (any-PUM). The annual number of days of each PUM exposure was also examined.

resultsCompared with VA-only users, dual users had more than double the odds of exposure to any-PUM (odds ratio [OR], 2.2 [95% CI, 2.2 to 2.3]), PUM-HEDIS (OR, 2.4 [CI, 2.2 to 2.8]), and PUM-ACB (OR, 2.1 [CI, 2.0 to 2.2]). The odds of PUM-antipsychotic exposure were also greater in dual users (OR, 1.5 [CI, 1.4 to 1.6]). Dual users had an adjusted average of 44.1 additional days of any-PUM exposure (CI, 37.2 to 45.0 days). LIMITATION: Observational study design of veteran outpatients only.

conclusionAmong veterans with dementia, rates of PUM prescribing are significantly higher among dual-system users than with VA-only users. PRIMARY FUNDING SOURCE: U.S. Department of Veterans Affairs.

Indexed as

Inappropriate PrescribingAgedAmbulatory CareAntipsychotic AgentsDementiaHumansMedicare Part DRetrospective StudiesRisk FactorsUnited StatesUnited States Department of Veterans AffairsAntipsychotic Agents

Identifiers

PMID27919104
PMCPMC8048048

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.