Evidence map›Paper›PMID 27919026›Full record

ArticleScience signaling2016

Hindered cytoplasmic diffusion of inositol trisphosphate restricts its cellular range of action.

George D Dickinson, Kyle L Ellefsen, Silvina Ponce Dawson, John E Pearson, Ian Parker

Abstract read
In one paragraph

Article in Science signaling, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Pacemaking in the lymphatic system.The Journal of physiology · 2026
    Review
  2. Article
  3. Review
  4. Computational investigation of IPScientific reports · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. CaCold Spring Harbor perspectives in biology · 2019
    Review
  12. Spatial-temporal patterning of CaSeminars in cell & developmental biology · 2019
    Review
  13. Article
  14. A Model ofBulletin of mathematical biology · 2019
    Article
  15. Structure and Function of IPCold Spring Harbor perspectives in biology · 2019
    Review
  16. Changes in CaFrontiers in physiology · 2019
    Article
  17. Dynamic CaCell calcium · 2018
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

George D DickinsonDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA. dickinsg@uci.edu.
Kyle L EllefsenDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
Silvina Ponce DawsonDepartamento de Física, FCEN-UBA and IFIBA, CONICET, Buenos Aires, Argentina.
John E PearsonTheoretical Biology and Biophysics, T-10 MS K710, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Ian ParkerDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.

Funding

Multi-scale observation and modeling of IP3/Ca signalingR01GM065830 · NIGMS · UNIVERSITY OF CALIF-LOS ALAMOS NAT LAB · PI MAK, DON-ON DANIEL, PARKER, IAN · 2002 to 2017
$10.7M
Elementary Events of Intracellular Calcium SignalingR37GM048071 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PARKER, IAN · 2011 to 2020
$5.3M
Spatial Dynamics of Cellular Calcium SignalingF31GM119330 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ELLEFSEN, KYLE L · 2016 to 2017
$68k
NIGMS NIH HHS F31 GM119330NIGMS NIH HHS R01 GM065830NIGMS NIH HHS R37 GM048071
6 · The paper itself

Abstract

The range of action of intracellular messengers is determined by their rates of diffusion and degradation. Previous measurements in oocyte cytoplasmic extracts indicated that the Ca

Indexed as

Calcium SignalingCalciumCell Line, TumorCytoplasmHumansInositol 1,4,5-TrisphosphateNeuroblastomaCalciumInositol 1,4,5-Trisphosphate

Identifiers

PMID27919026
PMCPMC5516629

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.