Evidence map›Paper›PMID 27918982›Full record

ArticleEnvironmental research2017

Traffic-derived particulate matter exposure and histone H3 modification: A repeated measures study.

Yinan Zheng, Marco Sanchez-Guerra, Zhou Zhang, Brian T Joyce, Jia Zhong, Jacob K Kresovich, Lei Liu, Wei Zhang, Tao Gao, Dou Chang and 13 more

Open access · greenAbstract read
In one paragraph

Article in Environmental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Pooled it
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  4. Health effects of air pollution on chronic respiratory diseases.The Korean journal of internal medicine · 2026
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  7. Air pollution and alveolar health.European respiratory review : an official journal of the European Respiratory Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 8 institutions in 6 countries.

Yinan ZhengDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Health Sciences Integrated PhD Program, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Marco Sanchez-GuerraDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Developmental Neurobiology, National Institute of Perinatology, Mexico City, Mexico.
Zhou ZhangDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Driskill Graduate Program in Life Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Brian T JoyceDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Division of Epidemiology/Biostatistics, School of Public Health, University of Illinois-Chicago, Chicago, IL, USA.
Jia ZhongDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Jacob K KresovichDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Division of Epidemiology/Biostatistics, School of Public Health, University of Illinois-Chicago, Chicago, IL, USA.
Lei LiuDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Robert H. Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Wei ZhangDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Robert H. Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Tao GaoDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Dou ChangDepartment of Safety Engineering, China Institute of Industrial Relations, Beijing, China.
Citlalli Osorio-YanezDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Juan Jose CarmonaDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Sheng WangDepartment of Occupational and Environmental Health, Peking University Health Science Center, Beijing, China.
John P McCrackenDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Xiao ZhangClinical Research Unit, Khoo Teck Puat Hospital, Singapore.
Yana ChervonaDepartment of Environmental Medicine, New York University Langone Medical Center, Tuxedo, NY, USA.
Anaite DíazCenter for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala.
Pier A BertazziDepartment of Clinical Sciences and Community Medicine, University of Milan and IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Petros KoutrakisDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Choong-Min KangDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Joel SchwartzDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Andrea A BaccarelliDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA. Electronic address: ab4303@cumc.columbia.edu.
Lifang HouDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Robert H. Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: l-hou@northwestern.edu.
Harvard University · USNorthwestern University · USChina University of Labor Relations · CNKhoo Teck Puat Hospital · SGNYU Langone Health · USPeking University · CNUniversidad del Valle de Guatemala · GTUniversity of Milan · IT

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Histone modifications and respiratory effects of traffic particle exposureR21ES020984 · NIEHS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BACCARELLI, ANDREA, HOU, LIFANG · 2012 to 2013
$455k
Micro-RNA Profiling and Cardiovascular Effects of Traffic Particle ExposureR21ES020010 · NIEHS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BACCARELLI, ANDREA, HOU, LIFANG · 2011 to 2012
$443k
Mitochondriomic Biomarkers of Air Pollution Exposure and Respiratory Function DecF32ES024068 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI CARMONA, JUAN JOSE · 2014 to 2014
$60k
NIEHS NIH HHS F32 ES024068NIEHS NIH HHS P30 ES009089NIEHS NIH HHS R21 ES020010NIEHS NIH HHS R21 ES020984
6 · The paper itself

Abstract

backgroundAirborne particulate matter (PM) may induce epigenetic changes that potentially lead to chronic diseases. Histone modifications regulate gene expression by influencing chromatin structure that can change gene expression status. We evaluated whether traffic-derived PM exposure is associated with four types of environmentally inducible global histone H3 modifications.

methodsThe Beijing Truck Driver Air Pollution Study included 60 truck drivers and 60 office workers examined twice, 1-2 weeks apart, for ambient PM

resultsIn all participants each μg/m

conclusionsOur results suggest a possible role of global histone H3 modifications in effects of traffic-derived PM exposures, particularly BC exposure. Future studies should assess the roles of these modifications in human diseases and as potential mediators of air pollution-induced disease, in particular BC exposure.

Indexed as

AcetylationAdolescentAdultBeijingEnvironmental ExposureFemaleHistonesHumansLeukocytesLysineMaleMethylationMiddle AgedParticulate MatterProtein Modification, TranslationalVehicle EmissionsHistonesLysineParticulate MatterVehicle EmissionsAcetylationEpigeneticsHistone H3MethylationParticulate matter

Identifiers

PMID27918982
PMCPMC5605137
OpenAlexW2560476717

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.