Evidence map›Paper›PMID 27918885›Full record

ArticleBiomaterials2017

Mutant CCL2 protein coating mitigates wear particle-induced bone loss in a murine continuous polyethylene infusion model.

Akira Nabeshima, Jukka Pajarinen, Tzu-Hua Lin, Xinyi Jiang, Emmanuel Gibon, Luis A Córdova, Florence Loi, Laura Lu, Eemeli Jämsen, Kensuke Egashira and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Arthrotomy-based preclinical models of particle-induced osteolysis: A systematic review.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017
    Pooled it
  2. Article
  3. Review
  4. Therapeutic effects of MSCs, genetically modified MSCs, and NFĸB-inhibitor on chronic inflammatory osteolysis in aged mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023
    Article
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  7. Article
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  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. The Effects of Biomaterial Implant Wear Debris on Osteoblasts.Frontiers in cell and developmental biology · 2020
    Review
  16. Review
  17. Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Akira NabeshimaDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.
Jukka PajarinenDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.
Tzu-Hua LinDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.
Xinyi JiangDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.
Emmanuel GibonDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.
Luis A CórdovaDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Chile, Santiago, Chile.
Florence LoiDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.
Laura LuDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.
Eemeli JämsenDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.
Kensuke EgashiraDepartment of Cardiovascular Research, Development, and Translational Medicine, Kyushu University, Fukuoka, Japan.
Fan YangDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA.
Zhenyu YaoDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.
Stuart B GoodmanDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA. Electronic address: goodbone@stanford.edu.
Stanford University · USKyushu University · JPUniversity of Chile · CL

Funding

Microribbon scaffold-mediated Immunomodulation for Cranial Bone RepairR01DE024772 · NIDCR · STANFORD UNIVERSITY · PI YANG, FAN · 2015 to 2025
$4.6M
Wear Particle Disease and NF-kappa B SignalingR01AR063717 · NIAMS · STANFORD UNIVERSITY · PI GOODMAN, STUART B · 2012 to 2021
$3.5M
Chemokine Directed Cell Trafficking during Continuous Infusion of Wear ParticlesR01AR055650 · NIAMS · STANFORD UNIVERSITY · PI GOODMAN, STUART B · 2007 to 2016
$3.3M
NIAMS NIH HHS R01 AR055650NIAMS NIH HHS R01 AR063717NIDCR NIH HHS R01 DE024772
6 · The paper itself

Abstract

Wear particle-induced osteolysis limits the long-term survivorship of total joint replacement (TJR). Monocyte/macrophages are the key cells of this adverse reaction. Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) is the most important chemokine regulating trafficking of monocyte/macrophages in particle-induced inflammation. 7ND recombinant protein is a mutant of CCL2 that inhibits CCL2 signaling. We have recently developed a layer-by-layer (LBL) coating platform on implant surfaces that can release biologically active 7ND. In this study, we investigated the effect of 7ND on wear particle-induced bone loss using the murine continuous polyethylene (PE) particle infusion model with 7ND coating of a titanium rod as a local drug delivery device. PE particles were infused into hollow titanium rods with or without 7ND coating implanted in the distal femur for 4 weeks. Specific groups were also injected with RAW 264.7 as the reporter macrophages. Wear particle-induced bone loss and the effects of 7ND were evaluated by microCT, immunohistochemical staining, and bioluminescence imaging. Local delivery of 7ND using the LBL coating decreased systemic macrophage recruitment, the number of osteoclasts and wear particle-induced bone loss. The development of a novel orthopaedic implant coating with anti-CCL2 protein may be a promising strategy to mitigate peri-prosthetic osteolysis.

Indexed as

AnimalsChemokine CCL2Coated Materials, BiocompatibleDrug ImplantsMaleMiceMice, NudeMutationOsteolysisPolyethyleneProstheses and ImplantsTreatment OutcomeCCL2 protein, humanChemokine CCL2Coated Materials, BiocompatibleDrug ImplantsPolyethyleneImplant coatingMacrophageMutant CCL2 proteinOsteolysisTotal joint replacement

Identifiers

PMID27918885
PMCPMC5180610
OpenAlexW2555070233

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.