Evidence map›Paper›PMID 27918836›Full record

ReviewAnnals of the New York Academy of Sciences2017

Evolvix BEST Names for semantic reproducibility across code2brain interfaces.

Laurence Loewe, Katherine S Scheuer, Seth A Keel, Vaibhav Vyas, Ben Liblit, Bret Hanlon, Michael C Ferris, John Yin, Inês Dutra, Anthony Pietsch and 25 more

Abstract readReview
In one paragraph

Review in Annals of the New York Academy of Sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Laurence LoeweWisconsin Institute for Discovery.
Katherine S ScheuerWisconsin Institute for Discovery.
Seth A KeelWisconsin Institute for Discovery.
Vaibhav VyasWisconsin Institute for Discovery.
Ben LiblitDepartments of Computer Sciences.
Bret HanlonStatistics.
Michael C FerrisWisconsin Institute for Discovery.
John YinWisconsin Institute for Discovery.
Inês DutraDepartment of Computer Science, University of Porto, Porto, Portugal.
Anthony PietschWisconsin Institute for Discovery.
Christine G JavidWisconsin Institute for Discovery.
Cecilia L MoogWisconsin Institute for Discovery.
Jocelyn MeyerWisconsin Institute for Discovery.
Jerdon DreselWisconsin Institute for Discovery.
Brian McLooneWisconsin Institute for Discovery.
Sonya LobergerWisconsin Institute for Discovery.
Arezoo MovagharWisconsin Institute for Discovery.
Morgaine Gilchrist-ScottWisconsin Institute for Discovery.
Yazeed SabriWisconsin Institute for Discovery.
Dave SescleiferWisconsin Institute for Discovery.
Ivan Pereda-ZorrillaWisconsin Institute for Discovery.
Andrew ZietlowWisconsin Institute for Discovery.
Rodrigo SmithWisconsin Institute for Discovery.
Samantha PietenpolWisconsin Institute for Discovery.
Jacob GoldfingerWisconsin Institute for Discovery.
Sarah L AtzenWisconsin Institute for Discovery.
Erika FreibergWisconsin Institute for Discovery.
Noah P WatersWisconsin Institute for Discovery.
Claire NusbaumWisconsin Institute for Discovery.
Erik NolanWisconsin Institute for Discovery.
Alyssa HotzWisconsin Institute for Discovery.
Richard M KlimanDepartment of Biology, Cedar Crest College, Allentown, Pennsylvania.
Ayalew MentewabDepartment of Biology, Spelman College, Atlanta, Georgia.
Nathan FregienCollege of the Menominee Nation, Keshena, Wisconsin.
Martha LoeweWisconsin Institute for Discovery.

Funding

Institutional Training in the Genomic SciencesT32HG002760 · NHGRI · UNIVERSITY OF WISCONSIN-MADISON · PI Qiongshi Lu · 2003 to 2026
$17.7M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007133 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PERNA, NICOLE T · 1985 to 2023
$16.5M
Fine-scale recombination, variation, divergence, and codon bias in DrosophilaR01GM086445 · NIGMS · DUKE UNIVERSITY · PI KLIMAN, RICHARD M, NOOR, MOHAMED A · 2009 to 2012
$1.4M
NHGRI NIH HHS T32 HG002760NIGMS NIH HHS R01 GM086445NIGMS NIH HHS T32 GM007133
6 · The paper itself

Abstract

Names in programming are vital for understanding the meaning of code and big data. We define code2brain (C2B) interfaces as maps in compilers and brains between meaning and naming syntax, which help to understand executable code. While working toward an Evolvix syntax for general-purpose programming that makes accurate modeling easy for biologists, we observed how names affect C2B quality. To protect learning and coding investments, C2B interfaces require long-term backward compatibility and semantic reproducibility (accurate reproduction of computational meaning from coder-brains to reader-brains by code alone). Semantic reproducibility is often assumed until confusing synonyms degrade modeling in biology to deciphering exercises. We highlight empirical naming priorities from diverse individuals and roles of names in different modes of computing to show how naming easily becomes impossibly difficult. We present the Evolvix BEST (Brief, Explicit, Summarizing, Technical) Names concept for reducing naming priority conflicts, test it on a real challenge by naming subfolders for the Project Organization Stabilizing Tool system, and provide naming questionnaires designed to facilitate C2B debugging by improving names used as keywords in a stabilizing programming language. Our experiences inspired us to develop Evolvix using a flipped programming language design approach with some unexpected features and BEST Names at its core.

Indexed as

Biological OntologiesBrain-Computer InterfacesCloud ComputingComputational BiologyData MiningHumansInternetProgramming LanguagesReproducibility of ResultsSoftwareSoftware DesignTerminology as Topicdebugging code2brain interfacesevolutionary systems biology simulationsflipped programming language designfundamental modes of computingnames of identifiers in codeontology computingprogramming language paradigms and naming

Identifiers

PMID27918836
PMCPMC5299481

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.