Trial reportMedicina oral, patologia oral y cirugia bucal2017
Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction.
Trial report in Medicina oral, patologia oral y cirugia bucal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review.BMJ open · 2021Pooled it
- Pooled it
- Conscious sedation for the management of dental anxiety in third molar extraction surgery: a systematic review.BMC oral health · 2020Pooled it
- Effects of ILIB on anxiety and physiological parameters during third molar surgery: a pilot randomized trial.Lasers in medical science · 2025Trial
- Effects of Passiflora incarnata on salivary biomarkers and anxiety in patients undergoing third molar extraction surgery.Scientific reports · 2025Trial
- Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial.Oral and maxillofacial surgery · 2024Trial
- The chronic effects of a combination of herbal extracts (EuphytoseJournal of psychopharmacology (Oxford, England) · 2022Trial
- Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial.Clinical oral investigations · 2021Trial
- Comparison of two vasoconstrictors on glycemic levels in diabetic patients.Clinical oral investigations · 2020Trial
- Clinical wear of approximal glass ionomer restorations protected with a nanofilled self-adhesive light-cured protective coating.Journal of applied oral science : revista FOB · 2018Trial
- Harmony in nature's elixir: a comprehensive exploration of ethanol and nano-formulated extracts from Passiflora incarnata leaves: unveiling in vitro cytotoxicity, acute and sub-acute toxicity profiles in Swiss albino mice.Journal of molecular histology · 2024Article
- Chemical Compositions, Pharmacological Properties and Medicinal Effects of GenusPlants (Basel, Switzerland) · 2024Review
- Article
- Nip it in the Bud: Botanicals for Anxiety - a Practical Prescriber's Guide.Current psychiatry reports · 2022Review
- Review
- Anxiety among patients undergoing various dental procedures.Bioinformation · 2022Article
- Herbal Medicinal Products fromTheScientificWorldJournal · 2020Review
- Conscious Sedation in Dentistry.Medicina (Kaunas, Lithuania) · 2019Article
- Psychodiagnostics as a Mandatory Element of Patient Protocols in Dentistry.Journal of International Society of Preventive & Community DentistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnxiety symptoms are frequently observed in dental patients, whether they are undergoing simple or more invasive procedures such as surgery. This research aimed to compare the effects of Passiflora incarnata and midazolam for the control of anxiety in patients undergoing mandibular third molar extraction. MATERIAL AND
methodsForty volunteers underwent bilateral extraction of their mandibular third molars in a randomized, controlled, double-blind, crossover clinical trial. Passiflora incarnata (260 mg) or midazolam (15 mg) were orally administered 30 minutes before surgery. The anxiety level of participants was evaluated by questionnaires and measurement of physical parameters, including heart rate (HR), blood pressure (BP), and oxygen saturation (SpO2).
resultsConsidering each procedure independently, there were no significant differences between the protocols in BP, HR, and SpO2. Over 70% of the volunteers responded that they felt quiet or a little anxious under both protocols. With midazolam, 20% of the participants reported amnesia (not remembering anything at all), while Passiflora showed little or no ability to interfere with memory formation.
conclusionsPassiflora incarnata showed an anxiolytic effect similar to midazolam, and was safe and effective for conscious sedation in adult patients who underwent extraction of their mandibular third molars.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.