ArticleNature genetics2017
Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders.
Article in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers, 12 of them syntheses that pooled it.
What it found
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Who cites it
175 citing papers in PubMed, 12 syntheses or guidelines pooled it, 455 citations in OpenAlex.
- A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology.Nature human behaviour · 2024Pooled it
- Pharmacogenomic scores in psychiatry: systematic review of current evidence.Translational psychiatry · 2024Pooled it
- Loneliness and depression: bidirectional mendelian randomization analyses using data from three large genome-wide association studies.Molecular psychiatry · 2023Pooled it
- Using Mendelian randomization analysis to better understand the relationship between mental health and substance use: a systematic review.Psychological medicine · 2021Pooled it
- The Relationship of Tinnitus Distress With Personality Traits: A Systematic Review.Frontiers in neurology · 2020Pooled it
- Personality characteristics below facets: A replication and meta-analysis of cross-rater agreement, rank-order stability, heritability, and utility of personality nuances.Journal of personality and social psychology · 2019Pooled it
- Multivariate genome-wide analyses of the well-being spectrum.Nature genetics · 2019Pooled it
- Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals.Molecular psychiatry · 2019Pooled it
- Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.Nature genetics · 2018Pooled it
- Dopamine genes are linked to Extraversion and Neuroticism personality traits, but only in demanding climates.Scientific reports · 2018Pooled it
- Pooled it
- Association study of genetic variation in DNA repair pathway genes and risk of basal cell carcinoma.International journal of cancer · 2017Pooled it
- Childhood Correlates of Genetic Propensity to Personality Traits.medRxiv : the preprint server for health sciences · 2026Article
- Genetic interconnections between personality-related phenotypes and psychiatric disorders.European archives of psychiatry and clinical neuroscience · 2026Article
- Article
- Dynamic neuro-immune regulation of psychiatric risk loci in human neurons.Nature communications · 2026Article
- Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo.Nature neuroscience · 2026Article
- Machine-Learning Decomposition Identifies a Big Two Structure in Human Personality with Distinct Neurocognitive Profiles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Early life exploration behaviour and life-history loci are colocalized in an adaptive genomic hotspot in Atlantic salmon.The Journal of animal ecology · 2026Article
- ADHD-anchored partitioning of non-small cell lung cancer genetic covariance identifiesFrontiers in immunology · 2026Article
115 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 6 institutions in 5 countries.
Funding
Abstract
Personality is influenced by genetic and environmental factors and associated with mental health. However, the underlying genetic determinants are largely unknown. We identified six genetic loci, including five novel loci, significantly associated with personality traits in a meta-analysis of genome-wide association studies (N = 123,132-260,861). Of these genome-wide significant loci, extraversion was associated with variants in WSCD2 and near PCDH15, and neuroticism with variants on chromosome 8p23.1 and in L3MBTL2. We performed a principal component analysis to extract major dimensions underlying genetic variations among five personality traits and six psychiatric disorders (N = 5,422-18,759). The first genetic dimension separated personality traits and psychiatric disorders, except that neuroticism and openness to experience were clustered with the disorders. High genetic correlations were found between extraversion and attention-deficit-hyperactivity disorder (ADHD) and between openness and schizophrenia and bipolar disorder. The second genetic dimension was closely aligned with extraversion-introversion and grouped neuroticism with internalizing psychopathology (e.g., depression or anxiety).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.