SynthesisNature genetics2017
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 2 pooled it
16.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 2 syntheses or guidelines pooled it, 145 citations in OpenAlex.
- A genome-wide cross-trait analysis identifies shared loci and causal relationships of obesity and lipidemic traits with psoriasis.Frontiers in immunology · 2024Pooled it
- Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.Human molecular genetics · 2019Pooled it
- AKR1C2 and AKR1C3 expression in adipose tissue: Association with body fat distribution and regulatory variants.Molecular and cellular endocrinology · 2021Trial
- Human Genetics of Adipose Dysfunction: Genomic Mechanisms and Therapeutic Opportunities in Cardiometabolic Disease.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Cardiovascular-kidney-metabolic syndrome as a mitochondrial systems disorder.Nature reviews. Nephrology · 2026Review
- Genetic Impacts on Variability of Body Fat Distribution Uncover Gene-Environment and Gene-Gene Interactions.bioRxiv : the preprint server for biology · 2026Article
- LYPLAL1 rare loss-of-function variants in humans and deletion in human hepatoma cells protect against MASLD.Journal of lipid research · 2026Article
- Towards Precision Medicine in Obesity: Genetic Copy Number Variations Profiling Linked to Specific Metabolic Dysregulation Patterns.International journal of molecular sciences · 2025Article
- Variant-to-function approaches for adipose tissue: Insights into cardiometabolic disorders.Cell genomics · 2025Review
- Non-canonical lysosomal lipolysis drives mobilization of adipose tissue energy stores with fasting.Nature communications · 2025Article
- Noncoding variation near UBE2E2 orchestrates cardiometabolic pathophenotypes through polygenic effectors.JCI insight · 2024Article
- Unhealthy visceral fat is associated with improved efficacy of immunotherapy in endometrial cancer.The Journal of clinical investigation · 2024Article
- Loss ofbioRxiv : the preprint server for biology · 2024Article
- The Expanding Problem of Regional Adiposity: Revisiting a 1985 Diabetes Classic by Ohlson et al.Diabetes · 2024Article
- SMYD3: a new regulator of adipocyte precursor proliferation at the early steps of differentiation.International journal of obesity (2005) · 2024Article
- Genetic correlation between chronic sinusitis and autoimmune diseases.Frontiers in allergy · 2024Article
- Genome-Wide Association Study of Pericardial Fat Area in 28 161 UK Biobank Participants.Journal of the American Heart Association · 2023Article
- E-GWAS: an ensemble-like GWAS strategy that provides effective control over false positive rates without decreasing true positives.Genetics, selection, evolution : GSE · 2023Article
- Causes of obesity: a review.Clinical medicine (London, England) · 2023Review
- Causal effect of adiposity on the risk of 19 gastrointestinal diseases: a Mendelian randomization study.Obesity (Silver Spring, Md.) · 2023Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
68 authors at 20 institutions in 6 countries.
Audrey Y ChuNHLBI's Framingham Heart Study, Framingham, Massachusetts, USA.
Xuan DengDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Virginia A FisherDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Alexander DrongWellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK.
Yang ZhangDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Mary F FeitosaDepartment of Genetics, Washington University, St. Louis, Missouri, USA.
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Olivia WeeksDivision of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Audrey C ChohDivision of Epidemiology and Biostatistics, Department of Population and Public Health Sciences, Wright State University Boonshoft School of Medicine, Dayton, Ohio, USA.
Qing DuanDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
Thomas D DyerSouth Texas Diabetes and Obesity Institute, University of Texas Health Science Center at San Antonio &University of Texas of the Rio Grande Valley, Brownsville, Texas, USA.
John D EicherNHLBI's Framingham Heart Study, Framingham, Massachusetts, USA.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Nancy L Heard-CostaDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0001-9730-0306
Tim KacprowskiInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0002-5393-2413
Jack W KentTOPS Nutrition and Obesity Research Center, Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Leslie A LangeDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
Xinggang LiuUniversity of Maryland School of Medicine, Baltimore, Maryland, USA.
Kurt LohmanWake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Lingyi LuDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Anubha MahajanWellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK.
Jeffrey R O'ConnellUniversity of Maryland School of Medicine, Baltimore, Maryland, USA.
Ankita PariharUniversity of Maryland School of Medicine, Baltimore, Maryland, USA.
Juan M PeraltaSouth Texas Diabetes and Obesity Institute, University of Texas Health Science Center at San Antonio &University of Texas of the Rio Grande Valley, Brownsville, Texas, USA.
Albert V SmithIcelandic Heart Association, Kopavogur, Iceland.ORCID 0000-0003-1942-5845
Yi ZhangTOPS Obesity and Metabolic Research Center, Biotechnology and Bioengineering Center, Department of Physiology at the Medical College of Wisconsin, Wisconsin, USA.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Ahmed H KissebahTOPS Obesity and Metabolic Research Center, Biotechnology and Bioengineering Center, Department of Physiology at the Medical College of Wisconsin, Wisconsin, USA.
Joel KullbergDepartment of Surgical Sciences, Section of Radiology, Uppsala University, Uppsala, Sweden.
René LaquaDepartment of Neuroradiology, University Hospital Berne, Berne, Switzerland.
Lenore J LaunerNational Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA.
Matthias NauckGerman Center for Cardiovascular Research (DZHK), Greifswald, Germany.
Michael OlivierTOPS Nutrition and Obesity Research Center, Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
James G TerryDepartment of Radiology and Radiologic Sciences, Department of Cardiovascular Medicine and Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Mary K WojczynskiDepartment of Genetics, Washington University, St. Louis, Missouri, USA.
Jie YaoInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
John BlangeroSouth Texas Diabetes and Obesity Institute, University of Texas Health Science Center at San Antonio &University of Texas of the Rio Grande Valley, Brownsville, Texas, USA.
Ingrid B BoreckiDepartment of Genetics, Washington University, St. Louis, Missouri, USA.
Donald W BowdenCenter for Genomics and Personalized Medicine Research, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA.
John Jeffrey CarrDepartment of Radiology and Radiologic Sciences, Department of Cardiovascular Medicine and Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-4398-8237
Stefan A CzerwinskiDepartment of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center (UTHealth) School of Public Health Brownsville Campus, Brownsville, Texas, USA.
Jingzhong DingWake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Nele FriedrichGerman Center for Cardiovascular Research (DZHK), Greifswald, Germany.
Vilmunder GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Tamara B HarrisNational Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA.
Erik IngelssonDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Andrew D JohnsonNHLBI's Framingham Heart Study, Framingham, Massachusetts, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Carl D LangefeldDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Lars LindDepartment of Surgical Sciences, Section of Radiology, Uppsala University, Uppsala, Sweden.
Yongmei LiuWake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Braxton D MitchellUniversity of Maryland School of Medicine, Baltimore, Maryland, USA.
Andrew P MorrisWellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK.
Thomas H MosleyUniversity of Mississippi Medical Center, Jackson, Mississippi, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Alan R ShuldinerUniversity of Maryland School of Medicine, Baltimore, Maryland, USA.
Bradford TowneDivision of Epidemiology and Biostatistics, Department of Population and Public Health Sciences, Wright State University Boonshoft School of Medicine, Dayton, Ohio, USA.
Henry VölzkeGerman Center for Cardiovascular Research (DZHK), Greifswald, Germany.
Henri WallaschofskiInstitute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Matthew AllisonDivision of Preventive Medicine, Department of Family Medicine and Public Health, University of California San Diego School of Medicine, San Diego, California, USA.
Cecilia M LindgrenLi Ka Shing Center for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK.
Wolfram GoesslingDivision of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-9972-1569
L Adrienne CupplesNHLBI's Framingham Heart Study, Framingham, Massachusetts, USA.
Matthew L SteinhauserDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Caroline S FoxNHLBI's Framingham Heart Study, Framingham, Massachusetts, USA.
Universitätsmedizin Greifswald · DEWake Forest University · USBoston University · USBrigham and Women's Hospital · USUniversity of Maryland, Baltimore · USCentre for Human Genetics · GBThe Lundquist Institute · USThe University of Texas Health Science Center at San Antonio · USUniversity of Michigan · USUppsala University · SEWashington University in St. Louis · USBroad Institute · USFramingham Heart Study · USJackson Memorial Hospital · USNational Institutes of Health · USTexas Biomedical Research Institute · USUniversity of Iceland · ISUniversity of North Carolina at Chapel Hill · USVanderbilt University Medical Center · USWright State University · US
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MCTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MWORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUNDLEY, WILLIAM GREGORY · 1992 to 2010
$35.2MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MCardiovascular Genomics and Bioinformatics projectsZIAHL006170 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI JOHNSON, ANDREW · 2013 to 2025
$25.3MZonulin Antibodies in Intestinal Permeabilitiy in IDDMM01RR016500 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI OSWALD, LYNN M · 2002 to 2009
$20.2MResearch BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3MSUBCUTANEOUS FAT, BLOOD LIPIDS AND SUBSEQUENT OUTCOMER01HD012252 · NICHD · WRIGHT STATE UNIVERSITY · PI CZERWINSKI, STEFAN A. · 1985 to 2014
$17.3MCANDIDATE GENE ASSOCIATION RESOURCE (CARE)N01HC65226 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2009
$17.0MMedical Research Council MR/N015355/1NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001881NCRR NIH HHS M01 RR007122NCRR NIH HHS M01 RR016500NCRR NIH HHS UL1 RR024156NEI NIH HHS ZIA EY000401NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS P50 HG004952NHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01HC65226NHLBI NIH HHS N02HL64278NHLBI NIH HHS R01 HL067348NHLBI NIH HHS R01 HL069313NHLBI NIH HHS R01 HL071205NHLBI NIH HHS R01 HL074168NHLBI NIH HHS R01 HL085323NHLBI NIH HHS R01 HL085571NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01 HL088451NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL117078NHLBI NIH HHS R01 HL119443NHLBI NIH HHS U01 HL067897NHLBI NIH HHS U01 HL072515NHLBI NIH HHS U01 HL084756NIAMS NIH HHS R01 AR046838NIAMS NIH HHS R01 AR048797NIAMS NIH HHS R01 AR052147NIA NIH HHS N01 AG012100NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS R01 AG028288NIA NIH HHS R01 AG032098NICHD NIH HHS R01 HD012252NICHD NIH HHS R01 HD053685NIDDK NIH HHS K08 DK090147NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK072488NIDDK NIH HHS R01 DK054026NIDDK NIH HHS R01 DK064391NIDDK NIH HHS R01 DK065598NIDDK NIH HHS R01 DK071891NIDDK NIH HHS R01 DK071895NIDDK NIH HHS R01 DK089256NIDDK NIH HHS R01 DK106236NIDDK NIH HHS R03 DK106477Wellcome Trust 098017Wellcome Trust WT064890Wellcome Trust WT090532
Abstract
Variation in body fat distribution contributes to the metabolic sequelae of obesity. The genetic determinants of body fat distribution are poorly understood. The goal of this study was to gain new insights into the underlying genetics of body fat distribution by conducting sample-size-weighted fixed-effects genome-wide association meta-analyses in up to 9,594 women and 8,738 men of European, African, Hispanic and Chinese ancestry, with and without sex stratification, for six traits associated with ectopic fat (hereinafter referred to as ectopic-fat traits). In total, we identified seven new loci associated with ectopic-fat traits (ATXN1, UBE2E2, EBF1, RREB1, GSDMB, GRAMD3 and ENSA; P < 5 × 10
Indexed as
Body Fat DistributionCell DifferentiationGenome-Wide Association StudyAdipocytesAnimalsCohort StudiesEthnicityFemaleGenetic LociGenetic MarkersGenetic Predisposition to DiseaseHumansMaleMiceMice, Inbred C57BLObesityGenetic Markers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.