ArticleNature neuroscience2017
A probabilistic approach to demixing odors.
Article in Nature neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Simultaneous detection and estimation in olfactory sensing.bioRxiv : the preprint server for biology · 2025Article
- Article
- Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal.Nature communications · 2025Article
- The primacy model and the structure of olfactory space.PLoS computational biology · 2024Article
- Haploinsufficiency ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Odor modality is transmitted to cortical brain regions from the olfactory bulb.Journal of neurophysiology · 2023Article
- Neural Circuits for Fast Poisson Compressed Sensing in the Olfactory Bulb.bioRxiv : the preprint server for biology · 2023Article
- Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal reward contingency signals during rule-reversal.bioRxiv : the preprint server for biology · 2023Article
- Robust odor identification in novel olfactory environments in mice.Nature communications · 2023Article
- Coupled Dynamics of Stimulus-Evoked Gustatory Cortical and Basolateral Amygdalar Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neural Circuits for Fast Poisson Compressed Sensing in the Olfactory Bulb.Advances in neural information processing systems · 2023Article
- Long-range functional loops in the mouse olfactory system and their roles in computing odor identity.Neuron · 2022Article
- Developmental and evolutionary constraints on olfactory circuit selection.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Disorder and the Neural Representation of Complex Odors.Frontiers in computational neuroscience · 2022Article
- Sparse connectivity for MAP inference in linear models using sister mitral cells.PLoS computational biology · 2022Article
- Article
- Paradoxical relationship between speed and accuracy in olfactory figure-background segregation.PLoS computational biology · 2021Article
- Representations of uncertainty: where art thou?Current opinion in behavioral sciences · 2021Review
- A spiking neural program for sensorimotor control during foraging in flying insects.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The olfactory system faces a hard problem: on the basis of noisy information from olfactory receptor neurons (the neurons that transduce chemicals to neural activity), it must figure out which odors are present in the world. Odors almost never occur in isolation, and different odors excite overlapping populations of olfactory receptor neurons, so the central challenge of the olfactory system is to demix its input. Because of noise and the large number of possible odors, demixing is fundamentally a probabilistic inference task. We propose that the early olfactory system uses approximate Bayesian inference to solve it. The computations involve a dynamical loop between the olfactory bulb and the piriform cortex, with cortex explaining incoming activity from the olfactory receptor neurons in terms of a mixture of odors. The model is compatible with known anatomy and physiology, including pattern decorrelation, and it performs better than other models at demixing odors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.