ArticleNature neuroscience2017
HSD2 neurons in the hindbrain drive sodium appetite.
Article in Nature neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 85 citations in OpenAlex.
- Molecular Ontology Predicts Output Connections From the Nucleus of the Solitary Tract.The Journal of comparative neurology · 2026Article
- Rapidly decreasing phasic dopamine responses precede a hedonic switch during satiation of sodium appetite.bioRxiv : the preprint server for biology · 2026Article
- Modulation of attractive salt taste iniScience · 2026Article
- AAV-PHP.eB Peripheral Delivery and Central Expression in Cre Mice.The Journal of comparative neurology · 2026Article
- Increased weight-bearing load reduces biological body weight while sodium and water balances are unaffected.Pflugers Archiv : European journal of physiology · 2025Article
- Flexible value coding in the mesolimbic dopamine system depending on internal water and sodium balance.NPJ science of food · 2025Article
- Serotonin neurons are necessary for tonic sodium intake inhibition.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Targeted cravings: Unraveling the drivers of nutrient-specific appetite.Current opinion in neurobiology · 2025Review
- Chemogenetic suppression of NST GABA neurons reveals inhibition of behavioral responses to sucrose and quinine.Physiology & behavior · 2025Article
- The neurobiology of thirst and salt appetite.Neuron · 2024Review
- Aldosterone-induced salt appetite requires HSD2 neurons.JCI insight · 2024Article
- Molecular Ontology of the Nucleus of Solitary Tract.The Journal of comparative neurology · 2024Article
- Suppression of neurons in circumventricular organs enables months-long survival without water in thirteen-lined ground squirrels.Science (New York, N.Y.) · 2024Article
- Control of sodium appetite by hindbrain aldosterone-sensitive neurons.Molecular and cellular endocrinology · 2024Review
- A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution.Nature communications · 2024Article
- Brain sodium sensing for regulation of thirst, salt appetite, and blood pressure.Physiological reports · 2024Review
- Article
- A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution.bioRxiv : the preprint server for biology · 2023Article
- Article
- Homeostatic Reinforcement Theory Accounts for Sodium Appetitive State- and Taste-Dependent Dopamine Responding.Nutrients · 2023Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sodium-depleted animals develop an appetite for aversive concentrations of sodium. Here we show that chemogenetic activation of aldosterone-sensitive neurons that express 11β-hydroxysteroid dehydrogenase type 2 (HSD2) in the nucleus of the solitary tract is sufficient to drive consumption of sodium-containing solutions in mice, independently of thirst or hunger. These HSD2-positive neurons are necessary for full expression of sodium appetite and have distinct downstream targets that are activated during sodium depletion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.