Evidence map›Paper›PMID 27918528›Full record

ArticleNature microbiology2016

Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster.

Natasha Arora, Verena J Schuenemann, Günter Jäger, Alexander Peltzer, Alexander Seitz, Alexander Herbig, Michal Strouhal, Linda Grillová, Leonor Sánchez-Busó, Denise Kühnert and 20 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Formal description ofInternational journal of systematic and evolutionary microbiology · 2026
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  4. Review
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  6. Review
  7. Frontiers in immunology · 2026
    Review
  8. Proteome Analysis of SevenJournal of proteome research · 2025
    Article
  9. Analysis ofmSphere · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. [Origin of Syphilis in Europe: End of a Controversy?]Medecine tropicale et sante internationale · 2025
    Article
  16. Article
  17. Establishment of the Nichols strain as the type strain ofInternational journal of systematic and evolutionary microbiology · 2025
    Review
  18. Article
  19. Review
  20. Article

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors.

Natasha AroraInstitute for Evolutionary Biology and Environmental Studies, University of Zurich, 8057 Zurich, Switzerland.
Verena J SchuenemannInstitute for Archaeological Sciences, University of Tübingen, 72070 Tübingen, Germany.
Günter JägerCenter for Bioinformatics, University of Tübingen, 72076 Tübingen, Germany.
Alexander PeltzerInstitute for Archaeological Sciences, University of Tübingen, 72070 Tübingen, Germany.
Alexander SeitzCenter for Bioinformatics, University of Tübingen, 72076 Tübingen, Germany.
Alexander HerbigInstitute for Archaeological Sciences, University of Tübingen, 72070 Tübingen, Germany.
Michal StrouhalDepartment of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.
Linda GrillováDepartment of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.
Leonor Sánchez-BusóUnidad Mixta Infección y Salud Pública FISABIO/Universidad de Valencia; CIBER in Epidemiology and Public Health, 46020, Spain.
Denise KühnertInstitute of Integrative Biology, Department of Environmental Systems Science, ETH Zürich, 8092 Zurich, Switzerland.
Kirsten I BosInstitute for Archaeological Sciences, University of Tübingen, 72070 Tübingen, Germany.
Leyla Rivero DavisInstitute for Evolutionary Biology and Environmental Studies, University of Zurich, 8057 Zurich, Switzerland.
Lenka MikalováDepartment of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.
Sylvia BruistenDepartment of Infectious Diseases, Public Health Laboratory, GGD Amsterdam, 1018 WT Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0003-4897-4261
Peter KomerickiDepartment of Dermatology, Medical University of Graz, A-8036 Graz, Austria.
Patrick FrenchThe Mortimer Market Centre CNWL, Camden Provider Services, London NW1 2PL, UK.
Paul R GrantDepartment of Clinical Microbiology and Virology, University College London Hospitals NHS Foundation Trust, London W1T 4EU, UK.
María A PandoInstituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires-CONICET, 1121 Buenos Aires, Argentina.
Lucía Gallo VauletFacultad de Farmacia y Bioquímica, Departamento de Bioquímica Clínica, Microbiología Clínica, Universidad de Buenos Aires, 1113 Buenos Aires, Argentina.
Marcelo Rodríguez FermepinFacultad de Farmacia y Bioquímica, Departamento de Bioquímica Clínica, Microbiología Clínica, Universidad de Buenos Aires, 1113 Buenos Aires, Argentina.ORCID http://orcid.org/0000-0003-2543-4262
Antonio MartinezServicio de Dermatología, Hospital General Universitario de Valencia, 46014 Valencia, Spain.
Arturo Centurion LaraDepartment of Medicine, Division of Allergy and Infectious Diseases, and Department of Global Health, University of Washington, Seattle, Washington 98105, USA.
Lorenzo GiacaniDepartment of Medicine, Division of Allergy and Infectious Diseases, and Department of Global Health, University of Washington, Seattle, Washington 98105, USA.ORCID http://orcid.org/0000-0003-3889-7274
Steven J NorrisDepartment of Pathology and Laboratory Medicine, UTHealth McGovern Medical School, Houston, Texas 77225, USA.
David ŠmajsDepartment of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.
Philipp P BosshardDepartment of Dermatology, University Hospital of Zurich, 8091 Zurich, Switzerland.
Fernando González-CandelasUnidad Mixta Infección y Salud Pública FISABIO/Universidad de Valencia; CIBER in Epidemiology and Public Health, 46020, Spain.
Kay NieseltCenter for Bioinformatics, University of Tübingen, 72076 Tübingen, Germany.
Johannes KrauseInstitute for Archaeological Sciences, University of Tübingen, 72070 Tübingen, Germany.
Homayoun C BagheriInstitute for Evolutionary Biology and Environmental Studies, University of Zurich, 8057 Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The abrupt onslaught of the syphilis pandemic that started in the late fifteenth century established this devastating infectious disease as one of the most feared in human history

Indexed as

Genetic VariationGenotypePandemicsAnti-Bacterial AgentsAzithromycinDNA, BacterialDrug Resistance, BacterialEvolution, MolecularGenome, BacterialGlobal HealthHumansMolecular EpidemiologyPhylogenySequence Analysis, DNASyphilisTreponema pallidumAnti-Bacterial AgentsAzithromycinDNA, Bacterial

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.