ArticleNature microbiology2016
Induction and suppression of antiviral RNA interference by influenza A virus in mammalian cells.
Open access · greenAbstract read
In one paragraph
Article in Nature microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 1 pooled it
13.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
101 citing papers in PubMed, 1 synthesis or guideline pooled it, 150 citations in OpenAlex.
- Pooled it
- Tuning intracellular immunity by Nodamura virus B2 protein enhances self-amplifying RNA activity.Nature communications · 2026Article
- Investigating the Role of microRNA in Host-Influenza A and Other Respiratory RNA Virus Interactions.Pathogens (Basel, Switzerland) · 2026Review
- Rational Design of Broad-Spectrum Anti-Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Induction of antiviral RNA interference by avian coronavirus IBV in PBMCs-Mφ.Cell communication and signaling : CCS · 2026Article
- The integrated stress response suppresses antiviral RNA interference by autophagy-mediated degradation of the RNA-induced silencing complex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Host-virus molecular arms race: RNAi-mediated antiviral defense and viral suppressor of RNAi.Cell insight · 2025Review
- Article
- Antiviral RNA silencing in mammals: the importance of selecting the appropriate experimental model.Nucleic acids research · 2025Review
- Dicer is cleaved by the Leader protease encoded by foot-and-mouth disease virus to promote infection in mammalian cells.Science advances · 2025Article
- Strategies and efforts in circumventing the emergence of antiviral resistance against conventional antivirals.npj antimicrobials and resistance · 2025Review
- SFTSV NSs interacts with AGO2 to regulate the RNAi pathway for viral replication.Journal of virology · 2025Article
- Nuclear AGO2 supports influenza A virus replication through type-I interferon regulation.Nucleic acids research · 2025Article
- Virus-derived siRNA: Coronavirus and influenza virus trigger antiviral RNAi immunity in birds.Nucleic acids research · 2025Article
- Targeting viral suppressor of RNAi confers anti-coronaviral activity.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Getting the host antiviral machinery back on track: Targeting viral suppressors of RNA interference.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Enhanced RNAi does not provide efficient innate antiviral immunity in mice.Nucleic acids research · 2025Article
- Catch me if you can: viral nucleic acids to host sensors.Frontiers in immunology · 2025Review
- Article
- microRNA-guided immunity against respiratory virus infection in human and mouse lung cells.Biology open · 2024Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
14 authors at 6 institutions in 4 countries.
Yang LiDepartment of Plant Pathology &Microbiology, and Institute for Integrative Genome Biology, University of California, Riverside, California 92521, USA.
Megha BasavappaGastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
Jinfeng LuDepartment of Plant Pathology &Microbiology, and Institute for Integrative Genome Biology, University of California, Riverside, California 92521, USA.
Shuwei DongDepartment of Plant Pathology &Microbiology, and Institute for Integrative Genome Biology, University of California, Riverside, California 92521, USA.
D Alexander CronkiteGastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
John T PriorGastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
Hans-Christian ReineckerGastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
Paul HertzogCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, 27-31 Wright Street, Clayton, Victoria 3168, Australia.
Yanhong HanDepartment of Plant Pathology &Microbiology, and Institute for Integrative Genome Biology, University of California, Riverside, California 92521, USA.
Wan-Xiang LiDepartment of Plant Pathology &Microbiology, and Institute for Integrative Genome Biology, University of California, Riverside, California 92521, USA.
Sihem CheloufiMassachusetts General Hospital, Cancer Center and Center for Regenerative Medicine and Harvard Stem Cell Institute, 185 Cambridge Street, Boston, Massachusetts 02114, USA.
Fedor V KarginovDepartment of Cell Biology and Neuroscience, University of California, Riverside, California 92521, USA.
Shou-Wei DingDepartment of Plant Pathology &Microbiology, and Institute for Integrative Genome Biology, University of California, Riverside, California 92521, USA.
Kate L JeffreyGastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
University of California, Riverside · USHarvard University · USMassachusetts General Hospital · USInstitut thématique Génétique, génomique et bioinformatique · FRFudan University · CNHudson Institute of Medical Research · AU
Funding
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MGene Silencing as an Antiviral Defense in Animal CellsR01AI052447 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI DING, SHOU-WEI · 2003 to 2016
$6.0MInnate Immune Defense Mechanisms in the IntestineR01AI113333 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI REINECKER, HANS-CHRISTIAN · 2014 to 2025
$5.7MAntigen Recognition at Intestinal Epithelial InterphasesR01DK068181 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI REINECKER, HANS-CHRISTIAN · 2005 to 2017
$5.2MArgonaute proteins in the mammalian antiviral responseR01AI107087 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI JEFFREY, KATE LOUISA · 2014 to 2018
$2.2MInducible Regulatory B cells IBREGR01AI081807 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI REINECKER, HANS-CHRISTIAN · 2011 to 2015
$1.9MIL-22 pathway in IBDR01DK091247 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI REINECKER, HANS-CHRISTIAN · 2013 to 2016
$1.4MAntiviral immunity directed by virus-derived small silencing RNAs in miceR56AI110579 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI DING, SHOU-WEI · 2015 to 2015
$372kNIAID NIH HHS R01 AI052447NIAID NIH HHS R01 AI081807NIAID NIH HHS R01 AI107087NIAID NIH HHS R01 AI113333NIAID NIH HHS R56 AI110579NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R01 DK068181NIDDK NIH HHS R01 DK091247
Abstract
Influenza A virus (IAV) causes annual epidemics and occasional pandemics, and is one of the best-characterized human RNA viral pathogens
Indexed as
Host-Pathogen InteractionsRNA InterferenceAnimalsArgonaute ProteinsCell LineChromatin ImmunoprecipitationHumansInfluenza A virusProtein BindingRNA, ViralViral Nonstructural ProteinsArgonaute ProteinsINS1 protein, influenza virusRNA, ViralViral Nonstructural Proteins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.