ArticleInternational journal of molecular sciences2016
Light/Dark Shifting Promotes Alcohol-Induced Colon Carcinogenesis: Possible Role of Intestinal Inflammatory Milieu and Microbiota.
Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- The TLR9 agonist MGN1703 triggers a potent type I interferon response in the sigmoid colon.Mucosal immunology · 2018Trial
- Timing matters: circadian rhythm disruption in alcohol-associated peripheral organ pathophysiology.Function (Oxford, England) · 2026Review
- Circadian Rhythms in Gastroenterology: The Biological Clock's Impact on Gut Health.Gastroenterology · 2025Review
- Article
- Sleep health: an unappreciated key player in colorectal cancer.Journal of Cancer · 2025Review
- Circadian Rhythm Perturbation Aggravates Gut Microbiota Dysbiosis in Dextran Sulfate Sodium-Induced Colitis in Mice.Nutrients · 2024Article
- Sleep Modulates Alcohol Toxicity inInternational journal of molecular sciences · 2022Article
- Behavioral circadian phenotypes are associated with the risk of elevated body mass index.Eating and weight disorders : EWD · 2022Article
- Circadian rhythms and the gut microbiota: from the metabolic syndrome to cancer.Nature reviews. Endocrinology · 2020Review
- Circadian rhythms in innate immunity and stress responses.Immunology · 2020Review
- Summary of the 2019 alcohol and immunology research interest group (AIRIG) meeting: Alcohol-mediated mechanisms of multiple organ injury.Alcohol (Fayetteville, N.Y.) · 2020Review
- Interaction of alcohol with time of eating on markers of circadian dyssynchrony and colon tissue injury.Chemico-biological interactions · 2020Article
- Intersection of the Gut Microbiome and Circadian Rhythms in Metabolism.Trends in endocrinology and metabolism: TEM · 2020Review
- Abnormal Eating Patterns Cause Circadian Disruption and Promote Alcohol-Associated Colon Carcinogenesis.Cellular and molecular gastroenterology and hepatology · 2020Article
- Risk of colorectal cancer in patients with alcoholism: A nationwide, population-based nested case-control study.PloS one · 2020Article
- Abnormal Food Timing Promotes Alcohol-Associated Dysbiosis and Colon Carcinogenesis Pathways.Frontiers in oncology · 2020Article
- Alcohol Effects on Colon Epithelium are Time-Dependent.Alcoholism, clinical and experimental research · 2019Article
- Circadian rhythms: a regulator of gastrointestinal health and dysfunction.Expert review of gastroenterology & hepatology · 2019Review
- Potential Role for the Gut Microbiota in Modulating Host Circadian Rhythms and Metabolic Health.Microorganisms · 2019Review
- Nutraceuticals in colorectal cancer: A mechanistic approach.European journal of pharmacology · 2018Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundColorectal cancer (CRC) is associated with the modern lifestyle. Chronic alcohol consumption-a frequent habit of majority of modern societies-increases the risk of CRC. Our group showed that chronic alcohol consumption increases polyposis in a mouse mode of CRC. Here we assess the effect of circadian disruption-another modern life style habit-in promoting alcohol-associated CRC.
methodTS4Cre × adenomatous polyposis coli (APC)
resultsThe combination of alcohol and LD shifting accelerated intestinal polyposis, with a significant increase in polyp size, and caused advanced neoplasia. Consistent with a pathogenic role of stromal tryptase-positive mast cells in colon carcinogenesis, the ratio of mMCP6 (stromal)/mMCP2 (intraepithelial) mast cells increased upon LD shifting. Baseline microbiota was similar between groups, and experimental manipulations resulted in a significant difference in the microbiota composition between groups.
conclusionsCircadian disruption by Light:dark shifting exacerbates alcohol-induced polyposis and CRC. Effect of circadian disruption could, at least partly, be mediated by promoting a pro-tumorigenic inflammatory milieu via changes in microbiota.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.