ReviewChildren (Basel, Switzerland)2016
Mental Health Comorbidities in Pediatric Chronic Pain: A Narrative Review of Epidemiology, Models, Neurobiological Mechanisms and Treatment.
Review in Children (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04561401 (Can Brain Stimulation Enhance Outcomes Associated With Intensive Rehabilitation for Youth With Chronic Pain?), which is not on this map. Cited by 85 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Can Brain Stimulation Enhance Outcomes Associated With Intensive Rehabilitation for Youth With Chronic Pain?
Who cites it
85 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review of the psychosocial factors associated with pain in children with juvenile idiopathic arthritis.Pediatric rheumatology online journal · 2023Pooled it
- A meta-analysis of the associations of elements of the fear-avoidance model of chronic pain with negative affect, depression, anxiety, pain-related disability and pain intensity.European journal of pain (London, England) · 2022Pooled it
- The Mediating Role of Pain Catastrophizing in Functioning and Mental Health for Youth With Pain-predominant Disorders of Gut-Brain Interaction.Journal of clinical gastroenterology · 2026Article
- Article
- Management of Pain and Pruritus in Pediatric Recessive Dystrophic Epidermolysis Bullosa.Clinical case reports · 2026Article
- Pain Assessment and Management in Pediatric Trauma Patients Transported to an Emergency Department: A Retrospective Cohort Study.Children (Basel, Switzerland) · 2026Article
- Co-occurring pediatric chronic pain and mental health: A genetically informed study.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- PURSUIT Protocol: Development of a Novel Approach to Managing Youth Physical and Mental Health in Schools.Children (Basel, Switzerland) · 2026Article
- Anti-inflammatory and analgesic potential of minor cannabinoids in vivo.Journal of cannabis research · 2026Article
- High impact chronic pain in children: exploration of associated characteristics and clinical factors in children and parents.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Mental health and substance use conditions among emerging adults in Australia 2020-2022: Prevalence, severity and psychosocial correlates within geographic regions.The Australian and New Zealand journal of psychiatry · 2026Article
- Educational support and weekly telemonitoring during rapid maxillary expansion in children: a prospective preference-based comparative cohort study.Frontiers in dental medicine · 2026Article
- The role of sleep deficiency in the relationship between adverse childhood experiences and early adolescent pain outcomes.JCPP advances · 2025Article
- Pediatric erythromelalgia from multidisciplinary perspectives: a scoping review.Pediatric research · 2025Article
- Longitudinal associations between chronic physical conditions, play behavior, and mental health problems in children.World journal of pediatrics : WJP · 2025Article
- Optimizing psychological treatments for pediatric chronic pain to enhance outcomes, availability, and accessibility.Current opinion in psychology · 2025Review
- Medical Post-Traumatic Stress Disorder Symptoms in Children and Adolescents with Chronic Inflammatory Arthritis: Prevalence and Associated Factors.Children (Basel, Switzerland) · 2025Article
- Parent Psychological Flexibility in Pediatric Chronic Pain.Child psychiatry and human development · 2025Article
- Transition of care readiness among adolescents with chronic pain between 2021-2022 in a Nationally representative sample.The journal of pain · 2025Article
- Pediatric Voluntary Habitual Hip Dislocation: Clinical Characteristics, Family Dynamics, and Long-Term Outcomes-A Retrospective Study.Journal of clinical medicine · 2025Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic pain during childhood and adolescence can lead to persistent pain problems and mental health disorders into adulthood. Posttraumatic stress disorders and depressive and anxiety disorders are mental health conditions that co-occur at high rates in both adolescent and adult samples, and are linked to heightened impairment and disability. Comorbid chronic pain and psychopathology has been explained by the presence of shared neurobiology and mutually maintaining cognitive-affective and behavioral factors that lead to the development and/or maintenance of both conditions. Particularly within the pediatric chronic pain population, these factors are embedded within the broader context of the parent-child relationship. In this review, we will explore the epidemiology of, and current working models explaining, these comorbidities. Particular emphasis will be made on shared neurobiological mechanisms, given that the majority of previous research to date has centered on cognitive, affective, and behavioral mechanisms. Parental contributions to co-occurring chronic pain and psychopathology in childhood and adolescence will be discussed. Moreover, we will review current treatment recommendations and future directions for both research and practice. We argue that the integration of biological and behavioral approaches will be critical to sufficiently address why these comorbidities exist and how they can best be targeted in treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.