ArticleLearning & memory (Cold Spring Harbor, N.Y.)2016
Subsecond fear discrimination in rats: adult impairment in adolescent heavy alcohol drinkers.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Article
- The effects of voluntary adolescent alcohol consumption on alcohol taste reactivity in Long Evans rats.Psychopharmacology · 2021Article
- Foot shock facilitates reward seeking in an experience-dependent manner.Behavioural brain research · 2021Article
- Early adolescent adversity alters periaqueductal gray/dorsal raphe threat responding in adult female rats.Scientific reports · 2020Article
- Anterior Cingulate Cortex Signals Attention in a Social Paradigm that Manipulates Reward and Shock.Current biology : CB · 2020Article
- The Nucleus Accumbens Core is Necessary to Scale Fear to Degree of Threat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The ventrolateral periaqueductal grey updates fear via positive prediction error.The European journal of neuroscience · 2020Article
- Article
- Voluntary ethanol consumption during early social isolation and responding for ethanol in adulthood.Alcohol (Fayetteville, N.Y.) · 2019Article
- Chemogenetic stimulation of the infralimbic cortex reverses alcohol-induced fear memory overgeneralization.Scientific reports · 2019Article
- Individual differences in voluntary alcohol consumption are associated with conditioned fear in the fear incubation model.Behavioural brain research · 2019Article
- Ventrolateral periaqueductal gray neurons prioritize threat probability over fear output.eLife · 2019Article
- Individual differences in conditioned fear are associated with levels of adolescent/early adult alcohol consumption and instrumental extinction.Behavioural brain research · 2018Article
- Early adolescent adversity inflates threat estimation in females and promotes alcohol use initiation in both sexes.Behavioral neuroscience · 2018Article
- Lateral orbitofrontal cortex partitions mechanisms for fear regulation and alcohol consumption.PloS one · 2018Article
- Adolescent Alcohol Drinking Renders Adult Drinking BLA-Dependent: BLA Hyper-Activity as Contributor to Comorbid Alcohol Use Disorder and Anxiety Disorders.Brain sciences · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Discriminating safety from danger must be accurate and rapid. Yet, the rapidity with which fear discrimination emerges remains unknown. Rapid fear discrimination in adulthood may be susceptible to impairment by adolescent heavy alcohol drinking, which increases incidence of anxiety disorders. Rats were given voluntary, adolescent alcohol access, and heavy drinkers were identified. In adulthood, rapid fear discrimination of safety, uncertainty, and danger cues was assessed. Normal rats, but not heavy drinkers, showed discriminative fear <1 sec following cue onset. This provides the first demonstration of subsecond fear discrimination and its adult impairment in adolescent heavy alcohol drinkers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.