ArticleLearning & memory (Cold Spring Harbor, N.Y.)2016
Stress-induced cortisol hampers memory generalization.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Review
- Stress disrupts hippocampal integration of overlapping events and memory inference in humans.Science advances · 2026Article
- Contextualizing cognition: Socio-environmental factors shape how momentary stress predicts memory.Social science & medicine (1982) · 2025Article
- Exploring stress hormone effects on memory specificity and strength in mice using the dual-event inhibitory avoidance task.Learning & memory (Cold Spring Harbor, N.Y.) · 2025Article
- Differential stress response to psychological and physical stressors in children using spatial versus response-dependent navigation strategies.Comprehensive psychoneuroendocrinology · 2021Article
- Across time and space: spatial-temporal binding under stress.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- The interaction between stress and chronic pain through the lens of threat learning.Neuroscience and biobehavioral reviews · 2019Review
- Stress leads to aberrant hippocampal involvement when processing schema-related information.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- A Deletion Variant of the α2b-Adrenoceptor Modulates the Stress-Induced Shift from "Cognitive" to "Habit" Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Integrative encoding and generalization across past experiences depends largely on the hippocampus, an area known to be particularly sensitive to stress. Yet, whether stress influences the ability to generalize memories is unknown. We exposed volunteers to a stressor or a control manipulation before they completed an acquired equivalence task probing memory generalization. While stress left learning performance intact, it reduced participants' ability to generalize and this deficit was directly linked to the cortisol response to the stressor. These findings show that stress, presumably through the action of glucocorticoids, creates rather rigid memories that are difficult to transfer to novel situations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.