ArticleScientific reports2016
Metagenomic profiling of historic Colorado Front Range flood impact on distribution of riverine antibiotic resistance genes.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Comparison of methods proposed for monitoring cefotaxime-resistantApplied and environmental microbiology · 2024Article
- Metagenomics indicate that public health risk may be higher from flooding following dry versus rainy periods.Environmental microbiology reports · 2022Article
- Article
- Antibiotic Resistome Biomarkers associated to the Pelagic Sediments of the Gulfs of Kathiawar Peninsula and Arabian Sea.Scientific reports · 2019Article
- Insights into the Bacterial Profiles and Resistome Structures Following the Severe 2018 Flood in Kerala, South India.Microorganisms · 2019Article
- NanoARG: a web service for detecting and contextualizing antimicrobial resistance genes from nanopore-derived metagenomes.Microbiome · 2019Article
- Prevalence of Antibiotic Resistance Genes in Air-Conditioning Systems in Hospitals, Farms, and Residences.International journal of environmental research and public health · 2019Article
- DirtyGenes: testing for significant changes in gene or bacterial population compositions from a small number of samples.Scientific reports · 2019Article
- High-Throughput Detection of Bacterial Community and Its Drug-Resistance Profiling From Local Reclaimed Wastewater Plants.Frontiers in cellular and infection microbiology · 2019Article
- Identification of key genes and pathways for esophageal squamous cell carcinoma by bioinformatics analysis.Experimental and therapeutic medicine · 2018Article
- Community structure explains antibiotic resistance gene dynamics over a temperature gradient in soil.FEMS microbiology ecology · 2018Article
- Partitioning of Antibiotic Resistance Genes and Fecal Indicators Varies Intra and Inter-Storm during Combined Sewer Overflows.Frontiers in microbiology · 2017Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Record-breaking floods in September 2013 caused massive damage to homes and infrastructure across the Colorado Front Range and heavily impacted the Cache La Poudre River watershed. Given the unique nature of this watershed as a test-bed for tracking environmental pathways of antibiotic resistance gene (ARG) dissemination, we sought to determine the impact of extreme flooding on ARG reservoirs in river water and sediment. We utilized high-throughput DNA sequencing to obtain metagenomic profiles of ARGs before and after flooding, and investigated 23 antibiotics and 14 metals as putative selective agents during post-flood recovery. With 277 ARG subtypes identified across samples, total bulk water ARGs decreased following the flood but recovered to near pre-flood abundances by ten months post-flood at both a pristine site and at a site historically heavily influenced by wastewater treatment plants and animal feeding operations. Network analysis of de novo assembled sequencing reads into 52,556 scaffolds identified ARGs likely located on mobile genetic elements, with up to 11 ARGs per plasmid-associated scaffold. Bulk water bacterial phylogeny correlated with ARG profiles while sediment phylogeny varied along the river's anthropogenic gradient. This rare flood afforded the opportunity to gain deeper insight into factors influencing the spread of ARGs in watersheds.
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