Evidence map›Paper›PMID 27917918›Full record

ArticleScientific reports2016

Distinct epigenomes in CD4

Ming Zhao, Jian Qin, Hanqi Yin, Yixin Tan, Wei Liao, Qian Liu, Shuangyan Luo, Min He, Gongping Liang, Yajing Shi and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Genomic Instability and Epigenetic Changes during Aging.International journal of molecular sciences · 2023
    Review
  5. Review
  6. Longevity, Centenarians and Modified Cellular Proteodynamics.International journal of molecular sciences · 2023
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Lack of Cell Cycle Inhibitor p21 and Low CD4Frontiers in immunology · 2021
    Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 1 country.

Ming ZhaoDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha 410011, PR. China.
Jian QinPublic Health College of Guangxi Medical University, Nanning 530021, PR. China.
Hanqi YinState Key Laboratory of Biocontrol, Sun Yat-sen University, Guangzhou 510275, PR. China.
Yixin TanDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha 410011, PR. China.
Wei LiaoDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha 410011, PR. China.
Qian LiuDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha 410011, PR. China.
Shuangyan LuoDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha 410011, PR. China.
Min HePublic Health College of Guangxi Medical University, Nanning 530021, PR. China.
Gongping LiangDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha 410011, PR. China.
Yajing ShiDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha 410011, PR. China.
Qing ZhangDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha 410011, PR. China.
Wenjun CaiBeijing Genomics Institute at Shenzhen, Shenzhen 518083, P.R. China.
Guangliang YinBeijing Genomics Institute at Shenzhen, Shenzhen 518083, P.R. China.
Yin ZhouDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha 410011, PR. China.
Jing WangDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha 410011, PR. China.
Mengying LiDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha 410011, PR. China.
Yi HuangDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha 410011, PR. China.
Aiyun LiuDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha 410011, PR. China.
Haijing WuDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha 410011, PR. China.
Zhiyong ZhangPublic Health College of Guangxi Medical University, Nanning 530021, PR. China.
Qianjin LuDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha 410011, PR. China.
Central South University · CNSecond Xiangya Hospital of Central South University · CNGuangxi Medical University · CNBGI Group (China) · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related variations in genes and microRNAs expression and DNA methylation have been reported respectively; however, their interactions during aging are unclear. We therefore investigated alterations in the transcriptomes, miRNAomes and DNA methylomes in the same CD4

Indexed as

DNA MethylationEpigenesis, GeneticTranscriptomeAged, 80 and overAgingCD4-Positive T-LymphocytesFemaleGene OntologyGene Regulatory NetworksHumansInfant, NewbornMaleMicroRNAsMiddle AgedMolecular Sequence AnnotationMicroRNAs

Identifiers

PMID27917918
PMCPMC5137168
OpenAlexW2560630567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.