Evidence map›Paper›PMID 27917890›Full record

ArticleScientific reports2016

A network intervention that locates and intervenes with recently HIV-infected persons: The Transmission Reduction Intervention Project (TRIP).

Georgios K Nikolopoulos, Eirini Pavlitina, Stephen Q Muth, John Schneider, Mina Psichogiou, Leslie D Williams, Dimitrios Paraskevis, Vana Sypsa, Gkikas Magiorkinis, Pavlo Smyrnov and 7 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07414459 (Combining Social Network Strategies and Routine Substance Use Screening), which is not on this map. Cited by 55 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 3 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07414459 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Combining Social Network Strategies and Routine Substance Use Screening

TypeinterventionalSponsorUniversity of California, San DiegoRan2026 to 2029Enrolled500ConditionsHIV, Substance Use Disorder (SUD)ArmsSubstance use disorder screening, Social network intervention
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.

  1. Pooled it
  2. A Review of Network Models for HIV Spread.Journal of acquired immune deficiency syndromes (1999) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 5 countries.

Georgios K NikolopoulosTransmission Reduction Intervention Project-Athens site, Athens, Greece.
Eirini PavlitinaTransmission Reduction Intervention Project-Athens site, Athens, Greece.
Stephen Q MuthQuintus-ential Solutions, Colorado Springs, Colorado, United States.
John SchneiderDepartment of Medicine and the Chicago Center for HIV Elimination, University of Chicago, Chicago, United States.
Mina PsichogiouLaikon General Hospital, First Department of Internal Medicine, Medical School, University of Athens, Athens, Greece.
Leslie D WilliamsNational Development and Research Institutes, New York City, United States.
Dimitrios ParaskevisDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, University of Athens, Athens, Greece.
Vana SypsaDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, University of Athens, Athens, Greece.
Gkikas MagiorkinisDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, University of Athens, Athens, Greece.
Pavlo SmyrnovAlliance for Public Health, Kyiv, Ukraine.
Anya KorobchukAlliance for Public Health, Kyiv, Ukraine.
Tetyana I VasylyevaDepartment of Zoology, University of Oxford, Oxford, UK.
Britt SkaathunDepartment of Medicine and the Chicago Center for HIV Elimination, University of Chicago, Chicago, United States.
Melpomeni MallioriMedical School, University of Athens, Athens, Greece.
Evangelos KafetzopoulosOrganization against Drugs (OKANA), Athens, Greece.
Angelos HatzakisDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, University of Athens, Athens, Greece.
Samuel R FriedmanNational Development and Research Institutes, New York City, United States.
National and Kapodistrian University of Athens · GRAlliance for Public Health · UANational Development and Research Institutes · USUniversity of Chicago · USNational Public Health Organization · GRUniversity of Cyprus · CYUniversity of Oxford · GB

Funding

The University of Chicago and Northwestern University Predoctoral Health Services Research Program-RenewalT32HS000084 · AHRQ · UNIVERSITY OF CHICAGO · PI KONETZKA, RITA TAMARA, MELTZER, DAVID O · 1998 to 2024
$7.6M
Preventing HIV Transmission by Recently-Infected Drug UsersDP1DA034989 · NIDA · NATIONAL DEVELOPMENT AND RESEARCH INSTITUTES, INC. · PI FRIEDMAN, SAMUEL R · 2012 to 2016
$3.8M
Social Network Dynamics, HIV, and Risk Reduction Among Younger Black MSMR01DA033875 · NIDA · NATIONAL OPINION RESEARCH CENTER · PI SCHNEIDER, JOHN · 2012 to 2016
$3.0M
Public health targeting of PrEP at HIV positives' bridging networksR21AI118998 · NIAID · UNIVERSITY OF CHICAGO · PI SCHNEIDER, JOHN · 2015 to 2016
$405k
AHRQ HHS T32 HS000084NIAID NIH HHS R21 AI118998NIDA NIH HHS DP1 DA034989NIDA NIH HHS R01 DA033875
6 · The paper itself

Abstract

Early treatment, soon after infection, reduces HIV transmissions and benefits patients. The Transmission Reduction Intervention Project (TRIP) evaluated a network intervention to detect individuals recently infected (in the past 6 months). TRIP was conducted in Greece (2013-2015) and focused on drug injector networks. Based on HIV status, testing history, and the results of an assay to detect recent infections, TRIP classified drug injector "Seeds" into groups: Recent Seeds (RS), and Control Seeds with Long-term HIV infection (LCS). The network members of RS and LCS were traced for two steps. The analysis included 23 RS, 171 network members of the RS, 19 LCS, and 65 network members of the LCS. The per-seed number of recents detected in the network of RS was 5 times the number in the network of LCS (Ratio RS vs. LCS: 5.23; 95% Confidence Interval (CI): 1.54-27.61). The proportion of recents among HIV positives in the network of RS (27%) was approximately 3 times (Ratio RS vs. LCS: 3.30; 95% CI: 1.04-10.43) that in the network of LCS (8%). Strategic network tracing that starts with recently infected persons could support public health efforts to find and treat people early in their HIV infection.

Indexed as

AdultFemaleGreeceHIV InfectionsHumansMalePublic HealthSocial Support

Identifiers

PMID27917890
PMCPMC5137009
OpenAlexW2559900932

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.