Evidence map›Paper›PMID 27917875›Full record

ArticleScientific reports2016

Exploring experimental cerebral malaria pathogenesis through the characterisation of host-derived plasma microparticle protein content.

Natalia Tiberti, Sharissa L Latham, Stephen Bush, Amy Cohen, Robert O Opoka, Chandy C John, Annette Juillard, Georges E Grau, Valéry Combes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 40 citations in OpenAlex.

  1. New therapeutic strategies for malaria.Biophysical reviews · 2025
    Review
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  15. Extracellular Vesicles and Cerebral Malaria.Sub-cellular biochemistry · 2021
    Article
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  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Natalia TibertiSchool of Life Sciences, Faculty of Sciences, University of Technology Sydney, Australia.
Sharissa L LathamVascular Immunology Unit, Department of Pathology, The University of Sydney, Australia.
Stephen BushSchool of Mathematical and Physical Sciences, University of Technology Sydney, Australia.
Amy CohenVascular Immunology Unit, Department of Pathology, The University of Sydney, Australia.
Robert O OpokaCollege of Health Sciences, Makerere University, Kampala, Uganda.
Chandy C JohnIndiana University School of Medicine, Indianapolis, United States of America.
Annette JuillardVascular Immunology Unit, Department of Pathology, The University of Sydney, Australia.
Georges E GrauVascular Immunology Unit, Department of Pathology, The University of Sydney, Australia.
Valéry CombesSchool of Life Sciences, Faculty of Sciences, University of Technology Sydney, Australia.
University of Sydney · AUUniversity of Technology Sydney · AUIndiana University – Purdue University Indianapolis · USMakerere University · UG

Funding

Severe Malaria And Risk to The Brain (SMART Brain)R01NS055349 · NINDS · UNIVERSITY OF MINNESOTA · PI Chandy C. John, Ruth Namazzi · 2008 to 2026
$11.2M
Microparticles, a new player in cerebral malaria pathogenesisR01NS079873 · NINDS · LA JOLLA INFECTIOUS DISEASE INSTITUTE · PI COMBES, VALERY MADELEINE · 2012 to 2015
$1.3M
NINDS NIH HHS R01 NS055349NINDS NIH HHS R01 NS079873
6 · The paper itself

Abstract

Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection responsible for thousands of deaths in children in sub-Saharan Africa. CM pathogenesis remains incompletely understood but a number of effectors have been proposed, including plasma microparticles (MP). MP numbers are increased in CM patients' circulation and, in the mouse model, they can be localised within inflamed vessels, suggesting their involvement in vascular damage. In the present work we define, for the first time, the protein cargo of MP during experimental cerebral malaria (ECM) with the overarching hypothesis that this characterisation could help understand CM pathogenesis. Using qualitative and quantitative high-throughput proteomics we compared MP proteins from non-infected and P. berghei ANKA-infected mice. More than 360 proteins were identified, 60 of which were differentially abundant, as determined by quantitative comparison using TMT

Indexed as

Plasmodium bergheiAnimalsBlood ProteinsBrainCalgranulin ACarbonic Anhydrase ICell-Derived MicroparticlesChildDisease Models, AnimalFlow CytometryGene Expression ProfilingGene Expression RegulationHumansMalaria, CerebralMiceMice, Inbred C57BLBlood ProteinsCalgranulin ACarbonic Anhydrase IS100a8 protein, mouse

Identifiers

PMID27917875
PMCPMC5137300
OpenAlexW2560561061

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.