Evidence map›Paper›PMID 27917827›Full record

ArticleActa crystallographica. Section D, Structural biology2016

The N14 anti-afamin antibody Fab: a rare V

Andreas Naschberger, Barbara G Fürnrohr, Tihana Lenac Rovis, Suzana Malic, Klaus Scheffzek, Hans Dieplinger, Bernhard Rupp

Open access · hybridAbstract read
In one paragraph

Article in Acta crystallographica. Section D, Structural biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Validation of ligands in macromolecular structures determined by X-ray crystallography.Acta crystallographica. Section D, Structural biology · 2018
    Article
  6. Review
  7. Twilight reloaded: the peptide experience.Acta crystallographica. Section D, Structural biology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Andreas NaschbergerDivision of Biological Chemistry, Medical University of Innsbruck, Innrain 80, 6020 Innsbruck, Austria.
Barbara G FürnrohrDivision of Biological Chemistry, Medical University of Innsbruck, Innrain 80, 6020 Innsbruck, Austria.
Tihana Lenac RovisCenter for Proteomics, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia.
Suzana MalicCenter for Proteomics, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia.
Klaus ScheffzekDivision of Biological Chemistry, Medical University of Innsbruck, Innrain 80, 6020 Innsbruck, Austria.
Hans DieplingerDivision of Genetic Epidemiology, Medical University of Innsbruck, Schöpfstrasse 41, 6020 Innsbruck, Austria.
Bernhard RuppDivision of Genetic Epidemiology, Medical University of Innsbruck, Schöpfstrasse 41, 6020 Innsbruck, Austria.
Universität Innsbruck · ATInnsbruck Medical University · ATUniversity of Rijeka · HR

Funding

Austrian Science Fund FWF P 28395
6 · The paper itself

Abstract

The monoclonal antibody N14 is used as a detection antibody in ELISA kits for the human glycoprotein afamin, a member of the albumin family, which has recently gained interest in the capture and stabilization of Wnt signalling proteins, and for its role in metabolic syndrome and papillary thyroid carcinoma. As a rare occurrence, the N14 Fab is N-glycosylated at Asn26L at the onset of the V

Indexed as

AnimalsAntibodies, MonoclonalAntigen-Antibody ComplexCarrier ProteinsComplementarity Determining RegionsCrystallography, X-RayGlycoproteinsGlycosylationHumansImmunoglobulin Fab FragmentsImmunoglobulin Variable RegionMiceModels, MolecularSerum AlbuminSerum Albumin, HumanAFM protein, humanAntibodies, MonoclonalAntigen-Antibody ComplexCarrier ProteinsComplementarity Determining RegionsGlycoproteinsImmunoglobulin Fab FragmentsImmunoglobulin Variable RegionSerum AlbuminSerum Albumin, Humanaccuracyantibody fragmentelbow angleflexibilitynon-apparent isomorphismprecisionsolventsolvent modellingvariable-chain glycosylation

Identifiers

PMID27917827
PMCPMC5137224
OpenAlexW2559200492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.