ArticleDevelopmental psychobiology2017
Maternal deprivation alters expression of neural maturation gene tbr1 in the amygdala paralaminar nucleus in infant female macaques.
Article in Developmental psychobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- Disrupted maternal care alters neural-microglia interactions in the primate paralaminar (PL) nucleus of the amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Postnatal maturation of the basolateral and paralaminar amygdala in rodents: implications for social-emotional development.Frontiers in neuroscience · 2026Review
- Multispecies characterization of immature neurons in the mammalian amygdala reveals their expansion in primates.PLoS biology · 2025Article
- Microglia Morphology in the Developing Primate Amygdala and Effects of Early Life Stress.eNeuro · 2025Article
- Delayed maturation and migration of excitatory neurons in the juvenile mouse paralaminar amygdala.Neuron · 2024Article
- The Development of Stress Reactivity and Regulation in Children and Adolescents.Current neuropharmacology · 2024Review
- Immature neurons in the primate amygdala: changes with early development and disrupted early environment.bioRxiv : the preprint server for biology · 2023Article
- Immature excitatory neurons in the amygdala come of age during puberty.Developmental cognitive neuroscience · 2022Article
- Effects of Early Life Stress on the Developing Basolateral Amygdala-Prefrontal Cortex Circuit: The Emerging Role of Local Inhibition and Perineuronal Nets.Frontiers in human neuroscience · 2021Review
- Social Isolation and Enrichment Induce Unique miRNA Signatures in the Prefrontal Cortex and Behavioral Changes in Mice.iScience · 2020Article
- Amygdala growth from youth to adulthood in the macaque monkey.The Journal of comparative neurology · 2019Article
- Immature excitatory neurons develop during adolescence in the human amygdala.Nature communications · 2019Article
- Maternal Deprivation Induces Memory Deficits That Are Reduced by One Aerobic Exercise Shot Performed after the Learning Session.Neural plasticity · 2019Article
- Social Origins of Developmental Risk for Mental and Physical Illness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
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Authors and funding
6 authors at 3 institutions in 1 country.
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Abstract
Early parental loss is associated with social-emotional dysregulation and amygdala physiologic changes. Previously, we examined whole amygdala gene expression in infant monkeys exposed to early maternal deprivation. Here, we focus on an amygdala region with immature neurons at birth: the paralaminar nucleus (PL). We hypothesized that 1) the normal infant PL is enriched in a subset of neural maturation (NM) genes compared to a nearby amygdala subregion; and 2) maternal deprivation would downregulate expression of NM transcripts (mRNA). mRNAs for bcl2, doublecortin, neuroD1, and tbr1-genes expressed in post-mitotic neurons-were enriched in the normal PL. Maternal deprivation at either 1 week or 1 month of age resulted in PL-specific downregulation of tbr1-a transcription factor necessary for directing neuroblasts to a glutamatergic phenotype. tbr1 expression also correlated with typical social behaviors. We conclude that maternal deprivation influences glutamatergic neuronal development in the PL, possibly influencing circuits mediating social learning.
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