Evidence map›Paper›PMID 27917409›Full record

ArticleACS omega2016

Gadolinium-Functionalized Peptide Amphiphile Micelles for Multimodal Imaging of Atherosclerotic Lesions.

Sang Pil Yoo, Federico Pineda, John C Barrett, Christopher Poon, Matthew Tirrell, Eun Ji Chung

Abstract read
In one paragraph

Article in ACS omega, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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  15. Calcium-binding nanoparticles for vascular disease.Regenerative engineering and translational medicine · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sang Pil YooInstitute for Molecular Engineering, University of Chicago , 5747 South Ellis Avenue, Chicago, Illinois, 60637, United States.
Federico PinedaDepartment of Radiology, University of Chicago , 5841 South Maryland Avenue, MC2026, Chicago, Illinois 60637, United States.
John C BarrettInstitute for Molecular Engineering, University of Chicago , 5747 South Ellis Avenue, Chicago, Illinois, 60637, United States.
Christopher PoonDepartment of Chemistry, University of Chicago , 929 E. 57th Street, Chicago, Illinois 60637, United States.
Matthew TirrellInstitute for Molecular Engineering, University of Chicago , 5747 South Ellis Avenue, Chicago, Illinois, 60637, United States.
Eun Ji ChungInstitute for Molecular Engineering, University of Chicago , 5747 South Ellis Avenue, Chicago, Illinois, 60637, United States.

Funding

Multimodal Peptide Amphiphile Micelles for AtherosclerosisR00HL124279 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHUNG, EUN JI PAIGE · 2016 to 2018
$747k
Multimodal Peptide Amphiphile Micelles for AtherosclerosisK99HL124279 · NHLBI · UNIVERSITY OF CHICAGO · PI CHUNG, EUN JI PAIGE · 2015 to 2016
$180k
NHLBI NIH HHS K99 HL124279NHLBI NIH HHS R00 HL124279
6 · The paper itself

Abstract

The leading causes of morbidity and mortality globally are cardiovascular diseases, and nanomedicine can provide many improvements including disease-specific targeting, early detection, and local delivery of diagnostic agents. To this end, we designed fibrin-binding, peptide amphiphile micelles (PAMs), achieved by incorporating the targeting peptide cysteine-arginine-glutamic acid-lysine-alanine (CREKA), with two types of amphiphilic molecules containing the gadoliniuim (Gd) chelator diethylenetriaminepentaacetic acid (DTPA), DTPA-bis(stearylamide)(Gd), and 1,2-distearoyl-

Identifiers

PMID27917409
PMCPMC5131325

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.