Evidence map›Paper›PMID 27917405›Full record

Trial reportThe lancet. Gastroenterology & hepatology2016

Efficacy and safety of 3-week response-guided triple direct-acting antiviral therapy for chronic hepatitis C infection: a phase 2, open-label, proof-of-concept study.

George Lau, Yves Benhamou, Guofeng Chen, Jin Li, Qing Shao, Dong Ji, Fan Li, Bing Li, Jialiang Liu, Jinlin Hou and 15 more

Registry-linked trialOpen access · greenAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The lancet. Gastroenterology & hepatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02470858 (Effect of Triple Direct Acting Antiviral Agents), which is not on this map. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02470858 phase2completednot on this map

Effect of Triple Direct Acting Antiviral Agents (DAAs) for Non-cirrhotic Subjects With Chronic HCV G1b Infection

TypeinterventionalSponsorHumanity and Health Research CentreRan2015 to 2015Enrolled18ConditionsChronic Hepatitis C InfectionArmsLDV/SOF+ASV, SOF+DCV+SMV, SOF+DCV+ASV
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Trial
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  11. Bemnifosbuvir: An HCV NS5B Inhibitor With Multiple Modes of Action.Clinical pharmacology and therapeutics · 2026
    Article
  12. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 1 institution in 1 country.

George LauDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Yves BenhamouDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Guofeng ChenDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Jin LiDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Qing ShaoDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Dong JiDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Fan LiDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Bing LiDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Jialiang LiuDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Jinlin HouDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Jian SunDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Cheng WangDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Jing ChenDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Vanessa WuDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
April WongDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Chris L P WongDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Stella T Y TsangDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Yudong WangDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Leda BassitDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Sijia TaoDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Yong JiangDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Hui-Mien HsiaoDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Ruian KeDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Alan S PerelsonDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
Raymond F SchinaziDivision of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).
MDS Associates (United States) · US

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Collaborative Integration of HCV Molecular Virology and Mathematical ModelingR01AI078881 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PERELSON, ALAN S, UPRICHARD, SUSAN L. · 2011 to 2025
$7.5M
Modeling Viral and T Lymphocyte DynamicsR01OD011095 · OD · TRIAD NATIONAL SECURITY, LLC · PI PERELSON, ALAN S · 2012 to 2024
$5.0M
Immune System Modeling/HIVR01AI028433 · NIAID · UNIVERSITY OF CALIF-LOS ALAMOS NAT LAB · PI PERELSON, ALAN S · 1990 to 2021
$3.7M
NIAID NIH HHS P30 AI050409NIAID NIH HHS R01 AI028433NIAID NIH HHS R01 AI078881NIH HHS R01 OD011095
6 · The paper itself

Abstract

backgroundTo shorten the course of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, we examined the antiviral efficacy and safety of 3 weeks of response-guided therapy with an NS3 protease inhibitor and dual NS5A inhibitor-NS5B nucleotide analogue.

methodsIn this open-label, phase 2a, single centre study, Chinese patients with chronic HCV genotype 1b infection without cirrhosis were randomly allocated by a computer program to one of three treatment groups (sofosbuvir, ledipasvir, and asunaprevir; sofosbuvir, daclatasvir, and simeprevir; or sofosbuvir, daclatasvir, and asunaprevir) until six patients in each group (1:1:1) achieved an ultrarapid virological response (plasma HCV RNA <500 IU/mL by day 2, measured by COBAS TaqMan HCV test, version 2.0). Patients with an ultrarapid virological response received 3 weeks of therapy. Patients who did not achieve an ultrarapid response were switched to sofosbuvir and ledipasvir for either 8 weeks or 12 weeks. The primary endpoint was the proportion of patients with a sustained virological response at 12 weeks (SVR12) after treatment completion, analysed in the intention-to-treat population. All patients who achieved an ultrarapid virological response were included in the safety analysis. This trial is registered with ClinicalTrials.gov, number NCT02470858.

findingsBetween April 5, 2015, and April 15, 2015, 26 eligible patients were recruited. 12 patients were assigned to sofosbuvir, ledipasvir, and asunaprevir; six to sofosbuvir, daclatasvir, and simeprevir; and eight to sofosbuvir, daclatasvir, and asunaprevir. Six patients in each group achieved an ultrarapid virological response (18 [69%]). All patients with an ultrarapid virological response who were given 3 weeks of triple therapy achieved SVR12. The most common adverse events were fatigue (one [17%] of six patients receiving sofosbuvir, ledipasvir, and asunaprevir; one [17%] of six patients receiving sofosbuvir, daclatasvir, and simeprevir; and two [33%] of six patients receiving sofosbuvir, daclatasvir, and asunaprevir) and headache (one [17%] patient in each group). No patients experienced any serious adverse events.

interpretationIn this proof-of-concept study, all patients with chronic HCV without cirrhosis who achieved an ultrarapid virological response on triple direct-acting antiviral regimens by day 2 and received 3 weeks of treatment were cured, with excellent tolerability. By shortening the duration of therapy from the currently recommended 12 weeks to 3 weeks, we could drastically reduce the cost of therapy and the rate of adverse events. Further large-scale studies should be done to confirm our findings.

fundingCenter for AIDS Research, National Institutes of Health, US Department of Energy, National Center for Research Resources and the Office of Research Infrastructure Programs, Cheng Si-Yuan (China-International) Hepatitis Research Foundation, and Humanity and Health Medical Group.

Indexed as

Administration, OralAdultAgedAntiviral AgentsBenzimidazolesCarbamatesDrug Administration ScheduleDrug Therapy, CombinationFemaleFluorenesFollow-Up StudiesHepatitis C, ChronicHumansImidazolesIntention to Treat AnalysisIsoquinolinesAntiviral AgentsasunaprevirBenzimidazolesCarbamatesdaclatasvirFluorenesImidazolesIsoquinolinesledipasvirPyrrolidinesSimeprevirSofosbuvirSulfonamidesValine

Identifiers

PMID27917405
PMCPMC5131925
OpenAlexW2479444737

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.