ArticleSpringerPlus2016
The effect of N-acetyl cysteine (NAC) on aluminum phosphide poisoning inducing cardiovascular toxicity: a case-control study.
Article in SpringerPlus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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21 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Efficacy of intravenous N acetylcysteine as an adjuvant therapy in the treatment of acute aluminum phosphide Poisoning: a systematic review and meta-analysis.BMC pharmacology & toxicology · 2023Pooled it
- Successful survival after severe aluminum phosphide poisoning complicated by cardiogenic shock, atrial fibrillation and severe metabolic acidosis: a case report.Journal of medical case reports · 2026Article
- Article
- Therapeutic effects of NAC and CoQ10 on aluminium phosphide poisoning as an adjuvant therapy: A Pilot study.Toxicology reports · 2025Article
- The potential role of N-acetylcysteine as an adjuvant therapy in acute aluminum phosphide poisoning: a randomized clinical trial.Toxicology research · 2025Article
- The possible therapeutic role of intravenous lipid emulsion in acute aluminium phosphide poisoning: a randomized controlled clinical trial.Toxicology research · 2024Article
- Biochemical and histopathological changes in livers of rats poisoned with aluminum phosphide and treated with carrot extract.Environmental analysis, health and toxicology · 2023Article
- The therapeutic benefit of antioxidants on the outcome of acute aluminum phosphide poisoning: a systemic review and meta-analysis.Toxicology research · 2023Review
- Cardioprotective role of the coenzyme Q10 and coconut oil in acute aluminum phosphide poisoning: a randomized controlled clinical trial.Toxicology research · 2023Article
- Cardiotoxicity of some pesticides and their amelioration.Environmental science and pollution research international · 2021Review
- Clinical Profile and Treatment Outcome of Aluminum Phosphide Poisoning in Felege Hiwot Referral Hospital, Northwest Ethiopia: A Retrospective Study.Open access emergency medicine : OAEM · 2021Article
- An epidemiological study of poisoning cases in Babol (northern Iran) from 2015 to 2018.Caspian journal of internal medicine · 2021Article
- The Molecular Mechanism of Aluminum Phosphide poisoning in Cardiovascular Disease: Pathophysiology and Diagnostic Approach.Cardiovascular toxicology · 2020Review
- Antidotes for aluminum phosphide poisoning - An update.Toxicology reports · 2018Review
- Using Intra-Aortic Balloon Pump for Management of Cardiogenic Shock Following Aluminum Phosphide Poisoning; Report of 3 Cases.Emergency (Tehran, Iran) · 2018Article
- Does N-acetyl Cysteine Have Protective Effects in Acute Aluminum Phosphide Poisoning?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2017Article
- A Narrative Review of Acute Adult Poisoning in Iran.Iranian journal of medical sciences · 2017Review
- Reversible Myocardial Injury and Intraventricular Thrombus Associated with Aluminium Phosphide Poisoning.Case reports in cardiology · 2017Article
- Prevention of phosphine-induced cytotoxicity by nutrients in HepG2 cells.The Indian journal of medical research · 2016Article
- Toxicoepidemiology of Phosphide Poisoning in the Central Part of Iran.Journal of research in pharmacy practiceArticle
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAluminum phosphide (AlP) is a very effective indoor and outdoor pesticide. We investigated the effects of N-acetyl cysteine (NAC) on the survival time, hemodynamics, and cardiac biochemical parameters at various time intervals in some cases of AlP poisoning.
methodsThis research was a case-control study to evaluate 63 AlP poisoned patients during 2010-2012. Patients with cardiovascular complications of AlP to be treated with intravenous NAC plus conventional treatment were considered as the case group and compared with patients who did not receive NAC. NAC infusion was administered to the case group at 300 mg/kg for 20 h. The data gathered included age, sex, heart rate, Systolic blood pressure (SBP), creatine phosphokinase (CPK), creatine kinase MB (CK-MB), and ECG at the admission time and 12, 18, and 24 h after admission. Analysis of repeated measures was performed to check the variability of parameters over time.
resultsThe mean ages in the case and control groups were 26.65 ± 1.06 (19-37 years) and 28.39 ± 1.11 (18-37 years), respectively (P = 0.266). Most of the patients were female (56.5%). CK-MB means were significantly different between the two groups, but no differences between the other variables were observed. Also, CK-MB, CPK, heart rate, and systolic blood pressure means became significantly different over time (0, 12, 18, and 24 h) in both groups (P < 0.001). NAC prevented sharp heart rate fluctuations in AlP patients in the case group. Regarding the outcomes, 17 patients died (10 patients in the control and 7 patients in the case groups). No side-effects of NAC were observed.
conclusionOur patients could be managed by the positive role of NAC as the biochemical index of cardiotoxicity was found to elevate in both the case and control groups. Therefore, for the management protocol optimization, NAC evaluation should be done in further cases.
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