ArticleJournal of experimental psychopathology2016
The neurobiology of dispositional negativity and attentional biases to threat: Implications for understanding anxiety disorders in adults and youth.
Article in Journal of experimental psychopathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- 5-HTTLPR does not moderate the effect of attention bias modification for depression: a randomized sham-controlled trial.Translational psychiatry · 2025Trial
- Variability of attention bias in socially anxious adolescents: differences in fixation duration toward adult and adolescent face stimuli.Cognition & emotion · 2019Trial
- A Neurodevelopmental Model of Social Threat Sensitivity as a Mechanism Linking Fearful Temperament, Social Anxiety, and Depression in Youth.Journal of child and adolescent psychopharmacology · 2026Review
- Impact of serotonin transporter deficiency on parvalbumin- and neuropeptide Y-producing neurons of the lateral and basolateral amygdalar nuclei.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Personality Heterogeneity Shapes the Neural Organization of Conditioned Threat Learning.Research square · 2026Article
- Can Neuroscience Inform Peacebuilding?The European journal of neuroscience · 2026Article
- The Link Between Emotional Regulation and Impulsivity in Childhood Anxiety Disorder.Children (Basel, Switzerland) · 2026Article
- Attention Focusing Moderates the Association Between Parent Anxiety and Attention Bias to Threat in Youth with Social Anxiety Disorder.Child psychiatry and human development · 2026Article
- Predicting anxiety symptoms through gaze-directed attention: A mobile eye-tracking study of adolescents during a real-world speech task.Journal of anxiety disorders · 2025Article
- Pathways to adolescent social anxiety: Testing interactions between neural social reward function and perceived social threat in daily life.Development and psychopathology · 2025Article
- The Organization of Anxiety Symptoms Along the Threat Imminence Continuum.Current topics in behavioral neurosciences · 2025Review
- Adolescent social anxiety is associated with diminished discrimination of anticipated threat and safety in the bed nucleus of the stria terminalis.Journal of psychopathology and clinical science · 2025Article
- An Honest Reckoning With the Amygdala and Mental Illness.The American journal of psychiatry · 2024Review
- Information processing style and institutional trust as factors of COVID vaccine hesitancy.Scientific reports · 2024Article
- Annual Research Review: Neuroimmune network model of depression: a developmental perspective.Journal of child psychology and psychiatry, and allied disciplines · 2024Review
- Understanding anxiety symptoms as aberrant defensive responding along the threat imminence continuum.Neuroscience and biobehavioral reviews · 2023Review
- Personality predicts pre-COVID-19 to COVID-19 trajectories of transdiagnostic anxiety and depression symptoms.Journal of psychopathology and clinical science · 2023Article
- Insomnia and distress as mediators on the relationship from cyber-victimization to self-reported psychotic experiences: a binational study from Tunisia and Lebanon.BMC psychiatry · 2023Article
- The Amygdala and Depression: A Sober Reconsideration.The American journal of psychiatry · 2022Article
- A Mechanism-Based Approach to Anti-Aggression Psychotherapy in Borderline Personality Disorder: Group Treatment Affects Amygdala Activation and Connectivity.Brain sciences · 2021Article
Corrections and comments
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Authors and funding
7 authors.
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Abstract
When extreme, anxiety can become debilitating. Anxiety disorders, which often first emerge early in development, are common and challenging to treat, yet the neurocognitive mechanisms that confer increased risk have only recently begun to come into focus. Here we review recent work highlighting the importance of neural circuits centered on the amygdala. We begin by describing dispositional negativity, a core dimension of childhood temperament and adult personality and an important risk factor for the development of anxiety disorders and other kinds of stress-sensitive psychopathology. Converging lines of epidemiological, neurophysiological, and mechanistic evidence indicate that the amygdala supports stable individual differences in dispositional negativity across the lifespan and contributes to the etiology of anxiety disorders in adults and youth. Hyper-vigilance and attentional biases to threat are prominent features of the anxious phenotype and there is growing evidence that they contribute to the development of psychopathology. Anatomical studies show that the amygdala is a hub, poised to govern attention to threat via projections to sensory cortex and ascending neuromodulatory systems. Imaging and lesion studies demonstrate that the amygdala plays a key role in selecting and prioritizing the processing of threat-related cues. Collectively, these observations provide a neurobiologically-grounded framework for understanding the development and maintenance of anxiety disorders in adults and youth and set the stage for developing improved intervention strategies.
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