Evidence map›Paper›PMID 27917271›Full record

ArticleIranian journal of basic medical sciences2016

Favorable effects of progesterone on skin random flap survival in rats.

Lin Dingsheng, Liu Zengbing, Huang Dong

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Iranian journal of basic medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Effect of Angiogenesis in Bone Tissue Engineering.Annals of biomedical engineering · 2022
    Review
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lin DingshengDepartment of Orthopaedics, Southern Medical University, Guangdong No.2 Province people's Hospital, Guangdong, China; Department of Hand Surgeries, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Liu ZengbingDepartment of Orthopaedics, Southern Medical University, Guangdong No.2 Province people's Hospital, Guangdong, China; Department of Hand Surgeries, The No.4 People's Hospital of Hengshui, Hengshui, China.
Huang DongDepartment of Orthopaedics, Southern Medical University, Guangdong No.2 Province people's Hospital, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study is to determine the effects of progesterone treatment on the survival of random skin flaps. MATERIALS AND

methodsMcFarlane flaps were established and 40 male rats were randomly assigned to the progesterone-treated as the test group or normal saline-treated as the control group. Progesterone or normal saline (10 mg/kg) was administered intraperitoneally once daily. On postoperative day 2, malondialdehyde (MDA) and superoxide dismutase (SOD) were detected using test kits. Flap survival rates were evaluated with transparent graph paper under direct visualization, the levels of inflammation were examined by haematoxylin and eosin (H&E) staining, and the expression of vascular endothelial growth factor (VEGF) was immunohistochemically evaluated on day 7.

resultsCompared to that in the control group, the mean survival area was significantly larger in the progesterone group. SOD activity was increased significantly, but the MDA levels in the test group were decreased. H&E-stained slices revealed that inflammation was inhibited in the test group. VEGF expression markedly increased in the progesterone group.

conclusionThis study showed that progesterone administered intraperitoneally significantly improved random skin flap survival in rats.

Indexed as

Angiogenesisgrowth factorMalondialdehydeProgesteroneRandom skin flapSuperoxide dismutaseVascular endothelial –

Identifiers

PMID27917271
PMCPMC5126216

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