ArticleAfrican health sciences2016
Anticancer and antibacterial secondary metabolites from the endophytic fungus Penicillium sp. CAM64 against multi-drug resistant Gram-negative bacteria.
Article in African health sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Synthesis and in-vitro anti-proliferative with antimicrobial activity of new coumarin containing heterocycles hybrids.Scientific reports · 2023Article
- Efficacy ofMicroorganisms · 2023Article
- An Insight into an Olive Scab on the "Istrska Belica" Variety: Host-Pathogen Interactions and Phyllosphere Mycobiome.Microbial ecology · 2023Article
- Endophytic Penicillium species secretes mycophenolic acid that inhibits the growth of phytopathogenic fungi.Microbial biotechnology · 2023Article
- Intracellular Pathways and Mechanisms of Colored Secondary Metabolites in Cancer Therapy.International journal of molecular sciences · 2022Review
- Citromycin Isolated from the Antarctic Marine-Derived Fungi,Marine drugs · 2022Article
- Fungal Endophytes: A Potential Source of Antibacterial Compounds.Journal of fungi (Basel, Switzerland) · 2022Review
- Deep learning approaches for natural product discovery from plant endophytic microbiomes.Environmental microbiome · 2021Review
- Classification ofStudies in mycology · 2020Article
- Endophytic3 Biotech · 2020Review
- Bioprospecting potential and secondary metabolite profile of a novel sediment-derived fungusMycology · 2019Article
- Bacterial disease induced changes in fungal communities of olive tree twigs depend on host genotype.Scientific reports · 2019Article
- Infections interplay with non-communicable diseases.African health sciences · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe emergence of multiple-drug resistance bacteria has become a major threat and thus calls for an urgent need to search for new effective and safe anti-bacterial agents.
objectivesThis study aims to evaluate the anticancer and antibacterial activities of secondary metabolites from
methodsThe culture filtrate from the fermentation of
resultsThe fractionation of the crude extract afforded penialidin A-C (1-3), citromycetin (4), p-hydroxyphenylglyoxalaldoxime (5) and brefelfin A (6). All of the compounds tested here showed antibacterial activity (MIC = 0.50 - 128 µg/mL) against Gramnegative multi-drug resistance bacteria,
conclusionThe results obtained indicate that compounds 1-6 showed good antibacterial and anticancer activities with no toxicity to human red blood cells and normal Vero cells.
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Registered trials
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