ArticleFrontiers in plant science2016
Tomato FK506 Binding Protein 12KD (FKBP12) Mediates the Interaction between Rapamycin and Target of Rapamycin (TOR).
Article in Frontiers in plant science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Functional analysis of target of rapamycin in regulating mycelial growth and development in Penicillium italicum.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Functional characterisation of Target of Rapamycin (TOR) signalling in Physcomitrella.Plant cell reports · 2026Article
- Genome-Wide Identification and Expression Profiling ofInternational journal of molecular sciences · 2025Article
- TOR balances plant growth and cold tolerance by orchestrating amino acid-derived metabolism in tomato.Horticulture research · 2024Article
- The critical roles of three sugar-related proteins (HXK, SnRK1, TOR) in regulating plant growth and stress responses.Horticulture research · 2024Article
- Exploring the specialized metabolome of the plant pathogen Streptomyces sp. 11-1-2.Scientific reports · 2024Article
- Effect of interfering TOR signaling pathway on the biosynthesis of terpenoids inPlant signaling & behavior · 2023Article
- Silencing of the Target of Rapamycin Complex Genes Stimulates Tomato Fruit Ripening.Molecules and cells · 2022Article
- TOR inhibition primes immunity and pathogen resistance in tomato in a salicylic acid-dependent manner.Molecular plant pathology · 2022Article
- TARGET OF RAPAMYCIN is essential for asexual vegetative reproduction in Kalanchoë.Plant physiology · 2022Article
- FKBP-type peptidyl-prolyl cis-trans isomerase interacts with the movement protein of tomato leaf curl New Delhi virus and impacts viral replication in Nicotiana benthamiana.Molecular plant pathology · 2022Article
- NVP-BEZ235 Inhibits Renal Cell Carcinoma by Targeting TAK1 and PI3K/Akt/mTOR Pathways.Frontiers in pharmacology · 2021Article
- Target of Rapamycin (TOR) Negatively Regulates Ethylene Signals inInternational journal of molecular sciences · 2020Article
- Wheat Germination Is Dependent on Plant Target of Rapamycin Signaling.Frontiers in cell and developmental biology · 2020Article
- Host-induced gene silencing of BcTOR in Botrytis cinerea enhances plant resistance to grey mould.Molecular plant pathology · 2019Article
- Cyclodipeptides fromPeerJ · 2019Article
- Nitrogen-dependent coordination of cell cycle, quiescence and TAG accumulation in Chlamydomonas.Biotechnology for biofuels · 2019Review
- Target of Rapamycin (TOR) Regulates the Expression of lncRNAs in Response to Abiotic Stresses in Cotton.Frontiers in genetics · 2018Article
- Target of rapamycin signaling orchestrates growth-defense trade-offs in plants.The New phytologist · 2018Article
- The TOR Signaling Network in the Model Unicellular Green Alga Chlamydomonas reinhardtii.Biomolecules · 2017Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Target of Rapamycin (TOR) signaling is an important regulator in multiple organisms including yeast, plants, and animals. However, the TOR signaling in plants is much less understood as compared to that in yeast and animals. TOR kinase can be efficiently suppressed by rapamycin in the presence of functional FK506 Binding Protein 12 KD (FKBP12) in yeast and animals. In most examined higher plants rapamycin fails to inhibit TOR kinase due to the non-functional FKBP12. Here we find that tomato plants showed obvious growth inhibition when treated with rapamycin and the inhibitory phenotype is similar to suppression of TOR causing by active-site TOR inhibitors (asTORis) such as KU63794, AZD8055, and Torin1. The chemical genetic assays using TOR inhibitors and heterologous expressing SlFKBP12 in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.