SynthesisNutrients2016
The Association between Weight Gain/Restoration and Bone Mineral Density in Adolescents with Anorexia Nervosa: A Systematic Review.
Synthesis in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Body composition in anorexia nervosa: Meta-analysis and meta-regression of cross-sectional and longitudinal studies.The International journal of eating disorders · 2019Pooled it
- Association of plasma levels of protein-bound advanced glycation end-products and their soluble receptors with bone mineral status in young girls with the restrictive type of anorexia nervosa.Archives of osteoporosis · 2025Article
- Loss of Bone Density in Patients with Anorexia Nervosa Food That Alone Will Not Cure.Nutrients · 2024Review
- Biochemical, hematologic, and skeletal features associated with underweight, overweight, and eating disorders in young Korean women: A population-based study.Frontiers in psychiatry · 2022Article
- Effects of low energy availability on female reproductive function.Reproductive medicine and biology · 2022Review
- Editorial: Nutrition and Health-Related Quality of Life: Is It an Ignored Outcome?Frontiers in nutrition · 2021Article
- Fertility and Reproduction after Recovery from Anorexia Nervosa: A Systematic Review and Meta-Analysis of Long-Term Follow-Up Studies.Diseases (Basel, Switzerland) · 2020Review
- Intensive weight gain therapy in patients with anorexia nervosa results in improved serum tartrate-resistant acid phosphatase (TRAP) 5a and 5b isoform protein levels.Eating and weight disorders : EWD · 2020Article
- Extreme anorexia nervosa: medical findings, outcomes, and inferences from a retrospective cohort.Journal of eating disorders · 2020Article
- Body Weight and Body Mass Index Influence Bone Mineral Density in Late Adolescence in a Two-Year Follow-Up Study. The Tromsø Study: Fit Futures.JBMR plus · 2019Article
- Medication in AN: A Multidisciplinary Overview of Meta-Analyses and Systematic Reviews.Journal of clinical medicine · 2019Review
- Bone health in adult women with ED: A longitudinal community-based study.Journal of psychosomatic research · 2019Article
- Factors influencing bone loss in anorexia nervosa: assessment and therapeutic options.RMD open · 2019Review
- Effects of Low Energy Availability on Reproductive Functions and Their Underlying Neuroendocrine Mechanisms.Journal of clinical medicine · 2018Review
- Adequate nutrition status important for bone mineral density improvement in a patient with anorexia nervosa.Therapeutics and clinical risk management · 2018Article
- Osteoporosis in Children with Chronic Illnesses: Diagnosis, Monitoring, and Treatment.Current osteoporosis reports · 2017Review
- Assessment and clinical management of bone disease in adults with eating disorders: a review.Journal of eating disorders · 2017Review
- Bone Mineral Density after Weight Gain in 160 Patients with Anorexia Nervosa.Frontiers in nutrition · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReduced bone mineral density (BMD) is one of the most frequent medical complications of anorexia nervosa (AN). The purpose of this paper was to conduct a systematic review of the association between weight gain/restoration and BMD in adolescents with AN.
methodsLiterature searches, study selection, method, and quality appraisal were performed independently by two authors, and data were collated using a narrative approach.
resultsOf the 1156 articles retrieved, 19 studies met the inclusion criteria, and their analysis revealed four main findings. First, six studies reported that weight gain and restoration are associated with BMD stabilization after one year of follow-up from baseline. Second, seven studies with longer follow-up periods (≈16 months) reported significant improvements in BMD measures. Third, one study showed that normalization of BMD can be achieved after ≈30-month follow-up of normal-weight maintenance. Fourth, another study showed that male adolescents with AN who achieve weight gain but remain underweight may experience further BMD loss, unlike their weight-restored counterparts (BMI ≥ 19 kg/m²), who show a significant increase in BMD and bone mineral accrual rates that double those of healthy male adolescents. The first two findings can be considered robust, as they are supported by strong evidence. The third and fourth findings, however, derive from single studies and therefore require further confirmation.
conclusionThe literature supports weight gain as an effective strategy for promoting BMD increase in adolescents with AN. However, this process is slow, and improvements do not become detectable until ≈16-month follow-up.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.