ArticleGastroenterology2017
Prevalence and Morbidity of Undiagnosed Celiac Disease From a Community-Based Study.
Article in Gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.
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Who cites it
66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 156 citations in OpenAlex.
- Relationship between vitamin D levels and pediatric celiac disease: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- Defining the optimum strategy for identifying adults and children with coeliac disease: systematic review and economic modelling.Health technology assessment (Winchester, England) · 2022Pooled it
- Linkage between HLA-B8 and HLA-DQ2.5 contributes to ancestry-dependent risk for celiac disease.Journal of human immunity · 2026Article
- The clinical utility of exome sequencing for risk stratification in celiac disease.Journal of human immunity · 2026Article
- Screen-Detected Coeliac Disease in a Nationally Representative Cohort: Health Indicators, Long-Term Outcomes and Mortality.Alimentary pharmacology & therapeutics · 2026Article
- Linkage between HLA-B8 and HLA-DQ2.5 Contributes to Ancestry-Dependent Genetic Risk for Celiac Disease.medRxiv : the preprint server for health sciences · 2026Article
- Micronutrient Deficiencies and Nutritional Status in Children with Celiac Disease: A Retrospective Study.Children (Basel, Switzerland) · 2026Article
- Mass Screening of Celiac Disease: A Crossing Point Between Secondary and Primary Prevention?Gastroenterology · 2026Article
- Small-fibre neuropathy in coeliac disease: a cross-sectional study.Frontiers in neurology · 2026Article
- Epilepsy and coeliac disease in children: a narrative review.Frontiers in pediatrics · 2026Review
- Intraepithelial Lymphocytes and LAIR1 Expression in Celiac Disease.Biomedicines · 2025Article
- Hypoalbuminemia as an Unusual Presentation of Undiagnosed Atypical Celiac Disease in an 84-Year-Old Woman.Annals of geriatric medicine and research · 2025Article
- Ritlecitinib, a JAK3 /TEC inhibitor, modulates the markers of celiac autoimmunity in alopecia areata and vitiligo patients.Archives of dermatological research · 2025Article
- From Inflammasomes to Pyroptosis: Molecular Mechanisms in Chronic Intestinal Diseases - Opportunity or Challenge?Journal of inflammation research · 2025Review
- A machine learning tool for early identification of celiac disease autoimmunity.Scientific reports · 2024Article
- Prevalence of celiac disease-specific antibodies and their association with clinical status and environmental factors.Heliyon · 2024Article
- Can diet change the natural history of gastrointestinal diseases?JGH open : an open access journal of gastroenterology and hepatology · 2024Review
- Autoimmune comorbidity in type 1 diabetes and its association with metabolic control and mortality risk in young people: a population-based study.Diabetologia · 2024Article
- Recurrent reproductive failure and celiac genetic susceptibility, a leading role of gluten.Frontiers in immunology · 2024Article
- Standardizing Randomized Controlled Trials in Celiac Disease: An International Multidisciplinary Appropriateness Study.Gastroenterology · 2024Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byReply.2017
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsLittle is known about the prevalence and burden of undiagnosed celiac disease in individuals younger than age 50. We determined the prevalence and morbidity of undiagnosed celiac disease in individuals younger than age 50 in a community.
methodsWe tested sera from 31,255 residents of Olmsted County, Minnesota (<50 y), without a prior diagnosis of celiac disease assay using an assay for IgA against tissue transglutaminase; in subjects with positive test results, celiac disease was confirmed using an assay for endomysial IgA. We performed a nested case-control study to compare the proportion of comorbidities between undiagnosed cases of celiac disease and age- and sex-matched seronegative controls (1:2). Medical records were abstracted to identify potential comorbidities.
resultsWe identified 338 of 30,425 adults with positive results from both serologic tests. Based on this finding, we estimated the prevalence of celiac disease to be 1.1% (95% confidence interval, 1.0%-1.2%); 8 of 830 children tested positive for IgA against tissue transglutaminase (1.0%; 95% confidence interval, 0.4%-1.9%). No typical symptoms or classic consequences of diagnosed celiac disease (diarrhea, anemia, or fracture) were associated with undiagnosed celiac disease. Undiagnosed celiac disease was associated with increased rates of hypothyroidism (odds ratio, 2.2; P < .01) and a lower than average cholesterol level (P = .03) and ferritin level (P = .01). During a median follow-up period of 6.3 years, the cumulative incidence of a subsequent diagnosis with celiac disease at 5 years after testing was 10.8% in persons with undiagnosed celiac disease vs 0.1% in seronegative persons (P < .01). Celiac disease status was not associated with overall survival.
conclusionsBased on serologic tests of a community population for celiac disease, we estimated the prevalence of undiagnosed celiac disease to be 1.1%. Undiagnosed celiac disease appeared to be clinically silent and remained undetected, but long-term outcomes have not been determined.
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