ArticleNeuron2016
A Sensor for Low Environmental Oxygen in the Mouse Main Olfactory Epithelium.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- A neuron-glia circuit anticipates hypoxia to regulate organismal oxygen use.bioRxiv : the preprint server for biology · 2026Article
- Glomeruli of the Mouse Olfactory Bulb: Numbers, Sizes, Shapes.The European journal of neuroscience · 2025Article
- Hemoglobin as an oxygen gasoreceptor.Acta biochimica Polonica · 2025Review
- Sensing and avoiding sick conspecifics requires Gαi2BMC biology · 2023Article
- Hypoxia sensing requires HScience advances · 2023Article
- Modulation of the NO-cGMP pathway has no effect on olfactory responses in theFrontiers in cellular neuroscience · 2023Article
- Optical Activation of Photoswitchable TRPC Ligands in the Mammalian Olfactory System Using Laser Scanning Confocal Microscopy.Methods in molecular biology (Clifton, N.J.) · 2023Article
- The role of ciliopathy-associated type 3 adenylyl cyclase in infanticidal behavior in virgin adult male mice.iScience · 2022Article
- A 3D transcriptomics atlas of the mouse nose sheds light on the anatomical logic of smell.Cell reports · 2022Article
- Reprogramming of glucocorticoid receptor function by hypoxia.EMBO reports · 2022Article
- Determining Candidate Hypobaric Hypoxia Profiles for Humane Killing of Laboratory Mice.Frontiers in veterinary science · 2022Article
- The De-Scent of Sexuality: Did Loss of a Pheromone Signaling Protein Permit the Evolution of Same-Sex Sexual Behavior in Primates?Archives of sexual behavior · 2021Article
- A diacylglycerol photoswitching protocol for studying TRPC channel functions in mammalian cells and tissue slices.STAR protocols · 2021Article
- Bidirectional Crosstalk Between Hypoxia Inducible Factors and Glucocorticoid Signalling in Health and Disease.Frontiers in immunology · 2021Review
- Olfactory subsystems associated with the necklace glomeruli in rodents.Cell and tissue research · 2021Review
- Ferritin is regulated by a neuro-intestinal axis in the nematode Caenorhabditis elegans.Redox biology · 2020Article
- Humanely Ending the Life of Animals: Research Priorities to Identify Alternatives to Carbon Dioxide.Animals : an open access journal from MDPI · 2019Article
- Bacterial MgrB peptide activates chemoreceptor Fpr3 in mouse accessory olfactory system and drives avoidance behaviour.Nature communications · 2019Article
- Alternatives to Carbon Dioxide-Taking Responsibility for Humanely Ending the Life of Animals.Animals : an open access journal from MDPI · 2019Article
- Central role of G protein Gαi2 and Gαi2Proceedings of the National Academy of Sciences of the United States of America · 2019Article
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sensing the level of oxygen in the external and internal environments is essential for survival. Organisms have evolved multiple mechanisms to sense oxygen. No function in oxygen sensing has been attributed to any mammalian olfactory system. Here, we demonstrate that low environmental oxygen directly activates a subpopulation of sensory neurons in the mouse main olfactory epithelium. These neurons express the soluble guanylate cyclase Gucy1b2 and the cation channel Trpc2. Low oxygen induces calcium influx in these neurons, and Gucy1b2 and Trpc2 are required for these responses. In vivo exposure of a mouse to low environmental oxygen causes Gucy1b2-dependent activation of olfactory bulb neurons in the vicinity of the glomeruli formed by axons of Gucy1b2+ sensory neurons. Low environmental oxygen also induces conditioned place aversion, for which Gucy1b2 and Trpc2 are required. We propose that this chemosensory function enables a mouse to rapidly assess the oxygen level in the external environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.