ArticleNeuron2016
Acute Fasting Regulates Retrograde Synaptic Enhancement through a 4E-BP-Dependent Mechanism.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- A retrograde, non-canonical integrated stress response cascade maintains synaptic strength under amino acid deprivation.Cell reports · 2025Article
- The translational inhibitor 4EBP/Thor is required for Drosophila adaptation to hypoxia.Scientific reports · 2025Article
- Glial Sphingosine-Mediated Epigenetic Regulation Stabilizes Synaptic Function inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Nutritional Programming of the Lifespan of Male Drosophila by Activating FOXO on Larval Low-Nutrient Diet.Nutrients · 2023Article
- A glutamate receptor C-tail recruits CaMKII to suppress retrograde homeostatic signaling.Nature communications · 2022Article
- Article
- Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience.Cell metabolism · 2021Review
- Synaptic homeostats: latent plasticity revealed at the Drosophila neuromuscular junction.Cellular and molecular life sciences : CMLS · 2021Review
- Article
- Skeletal muscle mTORC1 regulates neuromuscular junction stability.Journal of cachexia, sarcopenia and muscle · 2020Article
- Homeostatic control of Drosophila neuromuscular junction function.Synapse (New York, N.Y.) · 2020Review
- Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling.Nature communications · 2019Article
- Maintenance of homeostatic plasticity at theeLife · 2019Article
- Distinct homeostatic modulations stabilize reduced postsynaptic receptivity in response to presynaptic DLK signaling.Nature communications · 2018Article
- A postsynaptic PI3K-cII dependent signaling controller for presynaptic homeostatic plasticity.eLife · 2018Article
- Keeping Neurons Young and Foxy: FoxOs Promote Neuronal Plasticity.Trends in genetics : TIG · 2018Review
- Combining Constitutively Active Rheb Expression and Chondroitinase Promotes Functional Axonal Regeneration after Cervical Spinal Cord Injury.Molecular therapy : the journal of the American Society of Gene Therapy · 2017Article
- Development of a tissue-specific ribosome profiling approach in Drosophila enables genome-wide evaluation of translational adaptations.PLoS genetics · 2017Article
- Disparate Postsynaptic Induction Mechanisms Ultimately Converge to Drive the Retrograde Enhancement of Presynaptic Efficacy.Cell reports · 2017Article
- Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
While beneficial effects of fasting on organismal function and health are well appreciated, we know little about the molecular details of how fasting influences synaptic function and plasticity. Our genetic and electrophysiological experiments demonstrate that acute fasting blocks retrograde synaptic enhancement that is normally triggered as a result of reduction in postsynaptic receptor function at the Drosophila larval neuromuscular junction (NMJ). This negative regulation critically depends on transcriptional enhancement of eukaryotic initiation factor 4E binding protein (4E-BP) under the control of the transcription factor Forkhead box O (Foxo). Furthermore, our findings indicate that postsynaptic 4E-BP exerts a constitutive negative input, which is counteracted by a positive regulatory input from the Target of Rapamycin (TOR). This combinatorial retrograde signaling plays a key role in regulating synaptic strength. Our results provide a mechanistic insight into how cellular stress and nutritional scarcity could acutely influence synaptic homeostasis and functional stability in neural circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.