Evidence map›Paper›PMID 27916382›Full record

ArticleThe Journal of surgical research2016

Neochord placement versus triangular resection in mitral valve repair: A finite element model.

Ashley E Morgan, Joe L Pantoja, Eugene A Grossi, Liang Ge, Jonathan W Weinsaft, Mark B Ratcliffe

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in The Journal of surgical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Ashley E MorganEast Bay Surgical Residency, University of California, San Francisco, California.
Joe L PantojaCollege of Medicine, University of California, San Francisco, California.
Eugene A GrossiDepartment of Cardiothoracic Surgery, New York University, New York, New York; Department of Cardiothoracic Surgery, New York Harbor Veterans Affairs Medical Center, New York, New York.
Liang GeDepartment of Surgery, University of California, San Francisco, California; Department of Bioengineering, University of California, San Francisco, California; Department of Surgery, Veterans Affairs Medical Center, San Francisco, California.
Jonathan W WeinsaftDepartment of Medicine (Cardiology), Weill Cornell Medical College, New York, New York; Department of Radiology, Weill Cornell Medical College, New York, New York.
Mark B RatcliffeDepartment of Surgery, University of California, San Francisco, California; Department of Bioengineering, University of California, San Francisco, California; Department of Surgery, Veterans Affairs Medical Center, San Francisco, California. Electronic address: mark.ratcliffe@med.va.gov.
University of California, San Francisco · USCornell University · USSan Francisco VA Medical Center · USVA NY Harbor Healthcare System · US

Funding

VISUALIZATION TOOLS FOR AUTOMATED MOLECULAR MICROSCOPYP41RR008605 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCCULLOCH, ANDREW D. · 1994 to 2011
$28.1M
QUANTITATIVE ANALYSIS OF LEFT VENTRICULPLASTY--CHFR01HL063348 · NHLBI · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI RATCLIFFE, MARK B · 2000 to 2017
$6.8M
CMR Myocardial Tissue Based Prediction of Ischemic MR Revascularization ResponseR01HL128278 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI WEINSAFT, JONATHAN W. · 2015 to 2019
$3.8M
NCRR NIH HHS P41 RR008605NHLBI NIH HHS R01 HL063348NHLBI NIH HHS R01 HL128278
6 · The paper itself

Abstract

backgroundRecurrent mitral regurgitation after mitral valve repair is common, occurring in nearly 50% of patients within 10 years of surgery. Durability of repair is partly related to stress distribution over the mitral leaflets. We hypothesized that repair with neochords (NCs) results in lower stress than leaflet resection (LR). MATERIALS AND

methodsMagnetic resonance imaging and 3D echocardiography were performed before surgical repair of P2 prolapse in a single patient. A finite element model of the left ventricle and mitral valve was created previously, and the modeling program LS-DYNA was used to calculate leaflet stress for the following repairs: Triangular LR; LR with ring annuloplasty (LR + RA); One NC; Two NCs; and 2NC + RA.

results(1) NC placement resulted in stable posterior leaflet stress: Baseline versus 2 NC at end diastole (ED), 12.1 versus 12.0 kPa, at end systole (ES) 20.3 versus 21.7 kPa. (2) In contrast, LR increased posterior leaflet stress: Baseline versus LR at ED 12.1 versus 40.8 kPa, at ES 20.3 versus 46.1 kPa. (3) All repair types reduced anterior leaflet stress: Baseline versus 2 NC versus LR 34.2 versus 25.8 versus 20.6 kPa at ED and 80.8 versus 76.8 versus 67.8 kPa at ES. (4) The addition of RA reduced leaflet stress relative to repair without RA.

conclusionsNeochord repair restored normal leaflet coaptation without creating excessive leaflet stress, whereas leaflet resection more than doubled stress across the posterior leaflet. The excess stress created by leaflet resection was partially, but not completely, mitigated by ring annuloplasty.

Indexed as

Biomechanical PhenomenaFinite Element AnalysisHeart Valve Prosthesis ImplantationHumansMitral Valve AnnuloplastyMitral Valve InsufficiencyModels, AnatomicProsthesis DesignStress, MechanicalStress, PhysiologicalCardiac mechanicsFinite element modelingMitral valve repairSurgical simulation

Identifiers

PMID27916382
PMCPMC5142216
OpenAlexW2477934393

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.