Evidence map›Paper›PMID 27916353›Full record

Observational studyThe Journal of surgical research2016

Toll-like receptor responses are suppressed in trauma ICU patients.

Travis L Holloway, Susannah E Nicholson, Meenakshi Rani, Andrew P Cap, Martin G Schwacha

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of surgical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Travis L HollowayDepartment of Surgery, The University of Texas Health Science Center at San Antonio, Texas.
Susannah E NicholsonDepartment of Surgery, The University of Texas Health Science Center at San Antonio, Texas.
Meenakshi RaniDepartment of Surgery, The University of Texas Health Science Center at San Antonio, Texas.
Andrew P CapDepartment of Surgery, The University of Texas Health Science Center at San Antonio, Texas; Blood Research, US Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas.
Martin G SchwachaDepartment of Surgery, The University of Texas Health Science Center at San Antonio, Texas; Blood Research, US Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas. Electronic address: schwacha@uthscsa.edu.
The University of Texas Health Science Center at San Antonio · USUnited States Army Institute of Surgical Research · US

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1M
INSTITUTE FOR INTEGRATION OF MEDICINE & SCIENCE: A PARTNERSHIP TO IMPROVE HEALTHUL1RR025767 · NCRR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A · 2008 to 2011
$23.8M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR001120 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2013 to 2017
$16.5M
Injury, Ischemia and Inflammation: A Translational Approach to Trauma TreatmentT32GM079085 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SCHWACHA, MARTIN G · 2008 to 2012
$396k
NCATS NIH HHS UL1 TR001120NCI NIH HHS P30 CA054174NCRR NIH HHS UL1 RR025767NIGMS NIH HHS T32 GM079085
6 · The paper itself

Abstract

backgroundInflammation and activation of the innate immune system are often associated with traumatic injury and may involve alterations in toll-like receptor (TLR)-mediated responses.

methodsA prospective observational study was designed and conducted. Twenty-one severely injured (ISS = 16-41) trauma intensive care unit (ICU) patients and six healthy volunteers that served as controls were enrolled. Anticoagulated whole blood was collected at 2-12 d after ICU admission and incubated in the presence of media alone (baseline), zymosan (TLR2 agonist) or lipopolysaccharide (LPS; TLR4 agonist) for 3 h. Supernatant levels of inflammatory cytokines (IL-1β, IL-6, IL-10, and TNFα) were determined.

resultsTLR2-mediated and TLR4-mediated activation of whole blood cell cultures from both healthy volunteers and subjects-induced elevated cytokine levels over that observed in unstimulated cultures. Baseline values of IL-6 were significantly elevated in subject cultures as compared to healthy volunteers. Healthy volunteer cultures had 2-3-fold greater levels of IL-6 and TNFα than subject cultures when stimulated with zymosan (TLR2 agonist) or LPS (TLR4 agonist). IL-1β and IL-10 levels did not differ significantly between healthy volunteers and subjects.

conclusionsThe ability of circulating leukocytes from trauma ICU patients to be activated by TLR agonists is markedly suppressed and may play a role in the development of subsequent infectious complications.

Indexed as

AdolescentAdultAgedAged, 80 and overBiomarkersCase-Control StudiesCytokinesFemaleHumansIntensive Care UnitsLeukocytesLipopolysaccharidesMaleMiddle AgedProspective StudiesSalmonellaBiomarkersCytokinesLipopolysaccharidesTLR2 protein, humanTLR4 protein, humanToll-Like Receptor 2Toll-Like Receptor 4ZymosanCytokinesDAMPSInflammationPAMPsWhole blood

Identifiers

PMID27916353
PMCPMC5141258
OpenAlexW2467428987

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.