ArticleThe American journal of the medical sciences2016
Opiate Injection-associated Infective Endocarditis in the Southeastern United States.
Article in The American journal of the medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Controlled-release hydromorphone and risk of infection in adults: a systematic review.Harm reduction journal · 2023Pooled it
- Inpatient addiction care is associated with increased vaccinations, medication for opioid use disorder and naloxone prescribing among patients with infective endocarditis in a rural state.Addiction science & clinical practice · 2025Article
- The New Reality of Infective Endocarditis: Changes in Patient Demographics and Outcomes in South Carolina.Infectious disease reports · 2025Article
- Injection-Related Infections and Self-treatment Practices Among People Who Inject Drugs in Rural Appalachia.Open forum infectious diseases · 2025Article
- Features of infective endocarditis in a contemporary cohort of persons who inject drugs: a matched comparison analysis of long-term prognostic factors.Internal and emergency medicine · 2024Article
- Epidemiologic and clinical characteristics of infective endocarditis: a single-center retrospective study in the Bronx, New York.Infection · 2022Article
- Natural Language Processing and Machine Learning to Identify People Who Inject Drugs in Electronic Health Records.Open forum infectious diseases · 2022Article
- Correlates of 90-Day Mortality Among People Who Do and Do Not Inject Drugs With Infective Endocarditis in Seattle, Washington.Open forum infectious diseases · 2022Article
- The Feasibility and Utility of Harnessing Digital Health to Understand Clinical Trajectories in Medication Treatment for Opioid Use Disorder: D-TECT Study Design and Methodological Considerations.Frontiers in psychiatry · 2022Article
- Intravenous Drug Use-Associated Infective Endocarditis in Pregnant Patients at a Hospital in West Virginia.Cureus · 2021Article
- Association of Nonacute Opioid Use and Cardiovascular Diseases: A Scoping Review of the Literature.Journal of the American Heart Association · 2021Article
- Misclassification Error-Adjusted Prevalence of Injection Drug Use Among Infective Endocarditis Hospitalizations in the United States: A Serial Cross-Sectional Analysis of the 2007-2016 National Inpatient Sample.American journal of epidemiology · 2021Article
- Patients with infective endocarditis and history of injection drug use in a Swedish referral hospital during 10 years.BMC infectious diseases · 2021Article
- Emerging Viral and Bacterial Infections: Within an Era of Opioid Epidemic.Infectious diseases and therapy · 2020Review
- Longitudinal trends in nonmedical prescription opioid use in a cohort of rural Appalachian people who use drugs.Preventive medicine · 2020Article
- Opportunities to Offer Harm Reduction to People who Inject Drugs During Infectious Disease Encounters: Narrative Review.Open forum infectious diseases · 2020Review
- Changes in Infective Endocarditis Admissions in Pennsylvania During the Opioid Epidemic.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- National Public Health Burden Estimates of Endocarditis and Skin and Soft-Tissue Infections Related to Injection Drug Use: A Review.The Journal of infectious diseases · 2020Review
- Infective Endocarditis in Persons Who Use Drugs: Epidemiology, Current Management, and Emerging Treatments.Infectious disease clinics of North America · 2020Review
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOpiate pain reliever (OPR) misuse by injection is increasing in the United States. Infective endocarditis (IE), a devastating complication of injection OPR use, has been understudied.
methodsWe conducted a retrospective chart review of IE cases at an academic tertiary care hospital in North Carolina. Hospital admissions from 2009-2014 were screened for cases of definite IE. Subjects reporting injection drug use (IDU) were classified as IDU-IE, and compared to those without reported IDU, classified as No IDU-IE. Rates of IDU-IE and No IDU-IE, patient demographics, microbiologic data and outcomes were compared between the groups.
resultsA total of 127 incident admissions for IE were identified, 48 (37.8%) were classified as IDU-IE and 79 (62.2%) as No IDU-IE. IDU-IE cases increased from 14% of hospitalizations for IE in 2009 to 56% in 2014; reporting of OPR injection increased in 2012 and continued through the study period. IDU-IE subjects were younger (32.6 ± 11.7 versus 54.4 ± 13.1, P < 0.0001), more likely to be single (n = 33 [68.8%] versus n = 23 [29.1%], P < 0.0001) and to reside in rural communities (n = 36 [75.0%] versus n = 25 [31.6%], P < 0.0001) than No IDU-IE subjects. Hospital length of stay (26 days versus 12 days, P < 0.0001) and intensive care unit length of stay (2 days versus 1 day, P = 0.04) were longer for IDU-IE patients and hospital mortality did not differ (10.4% IDU-IE versus 8.9% No IDU-IE, P = 0.77).
conclusionsIDU-IE rates increased over time, and OPR injection use in rural communities appears to be a major contributor. Interventions to reduce IDU-IE and OPR misuse are needed to halt this growing epidemic in at-risk rural communities.
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