Evidence map›Paper›PMID 27915999›Full record

ArticleInfectious diseases of poverty2016

Predictors of mortality in a cohort of tuberculosis/HIV co-infected patients in Southwest Ethiopia.

Hailay Gesesew, Birtukan Tsehayneh, Desalegn Massa, Amanuel Gebremedhin, Hafte Kahsay, Lillian Mwanri

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Article in Infectious diseases of poverty, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 7 pooled it
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Hailay GesesewDepartment of Epidemiology, College of Health Sciences, Jimma University, Jimma, Ethiopia.
Birtukan TsehaynehDepartment of Epidemiology, College of Health Sciences, Jimma University, Jimma, Ethiopia.
Desalegn MassaDepartment of Epidemiology, College of Health Sciences, Jimma University, Jimma, Ethiopia.
Amanuel GebremedhinDepartment of population and Family Health, College of Health Sciences, Jimma University, Jimma, Ethiopia.
Hafte KahsayART Clinic, Filtu Hospital, Somali, Ethiopia.
Lillian MwanriDiscipline of Public Health, Faculty of Medicine, Nursing and Health Sciences, Flinders University, Adelaide, Australia. lillian.mwanri@flinders.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTuberculosis/HIV co-infection is a bidirectional and synergistic combination of two very important pathogens in public health. To date, there have been limited clinical data regarding mortality rates among tuberculosis/HIV co-infected patients and the impact of antiretroviral therapy on clinical outcomes in Ethiopia. This study assessed the incidence and predictors of tuberculosis/HIV co-infection mortality in Southwest Ethiopia.

methodsA retrospective cohort study collated tuberculosis/HIV data from Jimma University Teaching Hospital for the period of September 2010 and August 2012. The data analysis used proportional hazards cox regression model at P value of ≤ 0.05 in the final model.

resultsFifty-five (20.2 %) patients died during the study period and 272 study participants contributed 3 082.7 person month observations. Factors including: being aged between 35-44 years (AHR = 2.9; 95 % CI: 1.08-7.6), being a female sex worker (AHR = 9.1; 95 % CI: 2.7-30.7), being bed ridden as functional status (AHR = 3.2; 95 % CI: 1.2-8.7), and being at World Health Organization HIV disease stages 2 (AHR = 0.2; 95 % CI: 0.06-0.5), 3(AHR = 0.3; 95 % CI: 0.1-0.8) and 4(AHR = 0.2; 95 % CI: 0.04-0.55) were significant predictors of mortality for tuberculosis/HIV co-infected patients.

conclusionsContrary to our expectations, the World Health Organization (WHO) HIV disease stage 1 was found to be a significant predictor of mortality. Higher mortality rates were observed in WHO disease stage 1 patients compared to patients in stages 2, 3 and 4. The current study also confirmed and reaffirmed known significant predictors of the mortality for tuberculosis/HIV co-infected patients including being 35-44 years, being a female sex worker and being bed ridden functional status. The occurrence of high death rate among tuberculosis/HIV co-infected cases needs actions to reduce this poor outcome.

Indexed as

AdolescentAdultAgedAged, 80 and overAntitubercular AgentsCohort StudiesCoinfectionEthiopiaFemaleHIV InfectionsHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedMortalityAntitubercular AgentsCo-infectionEthiopiaHIVMortalityRetrospective cohortSurvivalTuberculosis

Identifiers

PMID27915999
PMCPMC5137204

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.